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    Nosip nitric oxide synthase interacting protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 292894, updated on 14-Nov-2024

    Summary

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    Official Symbol
    Nosipprovided by RGD
    Official Full Name
    nitric oxide synthase interacting proteinprovided by RGD
    Primary source
    RGD:1309992
    See related
    EnsemblRapid:ENSRNOG00000020543 AllianceGenome:RGD:1309992
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable molecular sequestering activity. Predicted to be involved in negative regulation of nitric-oxide synthase activity and regulation of nitric oxide biosynthetic process. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be active in nucleus. Orthologous to human NOSIP (nitric oxide synthase interacting protein). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 107.4), Heart (RPKM 106.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nosip in Genome Data Viewer
    Location:
    1q22
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (104679783..104695570)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (95543329..95559101)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (101055571..101072938)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene RAS related Neighboring gene proline rich 12 Neighboring gene proline rich and Gla domain 2 Neighboring gene reticulocalbin 3 Neighboring gene Fc gamma receptor and transporter

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Increased expression of nitric oxide synthase interacting protein (NOSIP) following traumatic spinal cord injury in rats. Yu X, et al. J Mol Histol, 2012 Dec. PMID 23135205
    2. Nitric oxide synthase (NOS)-interacting protein interacts with neuronal NOS and regulates its distribution and activity. Dreyer J, et al. J Neurosci, 2004 Nov 17. PMID 15548660, Free PMC Article
    3. NOSIP, a novel modulator of endothelial nitric oxide synthase activity. Dedio J, et al. FASEB J, 2001 Jan. PMID 11149895
    4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data suggested that NOSIP may play an important roles in astrogliogenesis after a spinal cord injury.
      Title: Increased expression of nitric oxide synthase interacting protein (NOSIP) following traumatic spinal cord injury in rats.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables molecular sequestering activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of catalytic activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of nitric-oxide synthase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of nitric oxide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    nitric oxide synthase-interacting protein
    NP_001099730.1
    XP_006229087.1
    XP_038960902.1
    XP_038960909.1
    XP_038960914.1
    XP_063140242.1
    XP_063140243.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106260.1 → NP_001099730.1  nitric oxide synthase-interacting protein

      See identical proteins and their annotated locations for NP_001099730.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473979
      UniProtKB/TrEMBL
      A0A8I6A6Q6, A6JAW4, D3ZH12
      Conserved Domains (2) summary
      pfam15906
      Location:4 → 78
      zf-NOSIP; Zinc-finger of nitric oxide synthase-interacting protein
      cd16662
      Location:220 → 284
      RING-Ubox2_NOSIP; U-box domain 2, a modified RING finger, found in nitric oxide synthase-interacting protein (NOSIP) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      104679783..104695570
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039104974.2 → XP_038960902.1  nitric oxide synthase-interacting protein isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZL30, A0A8I6A6Q6
      Conserved Domains (2) summary
      pfam15906
      Location:4 → 78
      zf-NOSIP; Zinc-finger of nitric oxide synthase-interacting protein
      cd16662
      Location:247 → 311
      RING-Ubox2_NOSIP; U-box domain 2, a modified RING finger, found in nitric oxide synthase-interacting protein (NOSIP) and similar proteins

    2. XM_006229025.3 → XP_006229087.1  nitric oxide synthase-interacting protein isoform X2

      See identical proteins and their annotated locations for XP_006229087.1

      UniProtKB/TrEMBL
      A0A8I6A6Q6, A6JAW4, D3ZH12
      Conserved Domains (2) summary
      pfam15906
      Location:4 → 78
      zf-NOSIP; Zinc-finger of nitric oxide synthase-interacting protein
      cd16662
      Location:220 → 284
      RING-Ubox2_NOSIP; U-box domain 2, a modified RING finger, found in nitric oxide synthase-interacting protein (NOSIP) and similar proteins

    3. XM_063284172.1 → XP_063140242.1  nitric oxide synthase-interacting protein isoform X2

      UniProtKB/TrEMBL
      A6JAW4, D3ZH12
      Related
      ENSRNOP00000027882.4, ENSRNOT00000027882.9

    4. XM_063284173.1 → XP_063140243.1  nitric oxide synthase-interacting protein isoform X2

      UniProtKB/TrEMBL
      A6JAW4, D3ZH12

    5. XM_039104981.1 → XP_038960909.1  nitric oxide synthase-interacting protein isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZL30, A0A8I6A6Q6
      Related
      ENSRNOP00000078514.1, ENSRNOT00000116790.2
      Conserved Domains (2) summary
      pfam15906
      Location:4 → 78
      zf-NOSIP; Zinc-finger of nitric oxide synthase-interacting protein
      cd16662
      Location:247 → 311
      RING-Ubox2_NOSIP; U-box domain 2, a modified RING finger, found in nitric oxide synthase-interacting protein (NOSIP) and similar proteins

    6. XM_039104986.2 → XP_038960914.1  nitric oxide synthase-interacting protein isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZL30, A0A8I6A6Q6
      Conserved Domains (2) summary
      pfam15906
      Location:4 → 78
      zf-NOSIP; Zinc-finger of nitric oxide synthase-interacting protein
      cd16662
      Location:247 → 311
      RING-Ubox2_NOSIP; U-box domain 2, a modified RING finger, found in nitric oxide synthase-interacting protein (NOSIP) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version

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