Myo9a myosin IXA [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Myo9aprovided by RGD
Official Full Name: myosin IXAprovided by RGD
Primary source: RGD:621395
See related: EnsemblRapid:ENSRNOG00000011619 AllianceGenome:RGD:621395
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: myr 7
Summary: Predicted to enable actin filament binding activity and microfilament motor activity. Predicted to be involved in several processes, including establishment of epithelial cell apical/basal polarity; postsynaptic specialization organization; and regulation of neuron projection arborization. Is active in glutamatergic synapse and postsynapse. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome. Orthologous to human MYO9A (myosin IXA). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 287.8), Lung (RPKM 217.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q24

Exon count:: 45

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (69044853..69248094)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (60149234..60352330)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (64573248..64777607)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH143491 (e-PCR)
- UniSTS:232738

MYO9A_8489 (e-PCR)
- UniSTS:467786

STS-F03912 (e-PCR)
- UniSTS:18387

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables microfilament motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables microfilament motor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in cell junction assembly	IEA Inferred from Electronic Annotation more info
involved_in cell junction assembly	ISO Inferred from Sequence Orthology more info
involved_in cell junction assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in establishment of epithelial cell apical/basal polarity	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of epithelial cell apical/basal polarity	IEA Inferred from Electronic Annotation more info
involved_in establishment of epithelial cell apical/basal polarity	ISO Inferred from Sequence Orthology more info
involved_in establishment of epithelial cell apical/basal polarity	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in postsynaptic specialization organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of neuron projection arborization	ISO Inferred from Sequence Orthology more info
involved_in regulation of neuron projection arborization	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in Schaffer collateral - CA1 synapse	ISO Inferred from Sequence Orthology more info
is_active_in actin filament	IBA Inferred from Biological aspect of Ancestor more info
is_active_in axonal growth cone	IBA Inferred from Biological aspect of Ancestor more info
located_in axonal growth cone	ISO Inferred from Sequence Orthology more info
located_in axonal growth cone	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in growth cone	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of myosin complex	IEA Inferred from Electronic Annotation more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: unconventional myosin-IXa

Names: myosin-IXa; unconventional myosin-9a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_134335.2 → NP_599162.2 unconventional myosin-IXa

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/Swiss-Prot

Q9Z1N3

UniProtKB/TrEMBL

A6J540, F1LMQ1

Related

ENSRNOP00000015963.6, ENSRNOT00000015963.8

Conserved Domains (5) summary

smart00015
Location:1115 → 1137

IQ; Calmodulin-binding motif

cd04406
Location:2129 → 2314

RhoGAP_myosin_IXA; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXA. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class ...

cd01385
Location:160 → 1005

MYSc_Myo9; class IX myosin, motor domain

cd17216
Location:15 → 110

RA_Myosin-IXa; Ras-associating (RA) domain found in Myosin-IXa

cd20883
Location:2063 → 2120

C1_Myosin-IXa; protein kinase C conserved region 1 (C1 domain) found in unconventional myosin-IXa and similar proteins