Strada STE20 related adaptor alpha [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Stradaprovided by RGD
Official Full Name: STE20 related adaptor alphaprovided by RGD
Primary source: RGD:727905
See related: EnsemblRapid:ENSRNOG00000008637 AllianceGenome:RGD:727905
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Lyk5
Summary: Contributes to protein serine/threonine kinase activity. Involved in activation of protein kinase activity. Part of protein-containing complex. Human ortholog(s) of this gene implicated in polyhydramnios, megalencephaly, and symptomatic epilepsy. Orthologous to human STRADA (STE20 related adaptor alpha). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Testes (RPKM 169.9), Adrenal (RPKM 95.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q32.1

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (91594648..91623710, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (91094849..91123890, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (94355369..94384404, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

local LKB1/STRAD accumulation and PKA-dependent LKB1 phosphorylation represents an early signal for axon initiation [STRAD protein]
Title: LKB1/STRAD promotes axon initiation during neuronal polarization.
LKB1 deacetylation is regulated by SIRT1 and that this in turn influences its intracellular localization, association with STRAD, kinase activity, and ability to activate AMPK.
Title: SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1. Possible role in AMP-activated protein kinase activation.

Submit: New GeneRIF Correction

General gene information

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Markers

RH142091 (e-PCR)
- UniSTS:224081

BI278319 (e-PCR)
- UniSTS:244340

BI295468 (e-PCR)
- UniSTS:246649

RH139256 (e-PCR)
- UniSTS:221342

D10Chm161 (e-PCR)
- UniSTS:518333

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase binding	IEA Inferred from Electronic Annotation more info
enables kinase binding	ISO Inferred from Sequence Orthology more info
enables protein kinase activator activity	ISO Inferred from Sequence Orthology more info
enables protein kinase activator activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
NOT enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activator activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activator activity	ISO Inferred from Sequence Orthology more info
contributes_to protein serine/threonine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in G1 to G0 transition	IEA Inferred from Electronic Annotation more info
acts_upstream_of_negative_effect G1 to G0 transition	ISO Inferred from Sequence Orthology more info
involved_in activation of protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within activation of protein kinase activity	ISO Inferred from Sequence Orthology more info
involved_in activation of protein kinase activity	ISO Inferred from Sequence Orthology more info
involved_in protein export from nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein export from nucleus	IEA Inferred from Electronic Annotation more info
involved_in protein export from nucleus	ISO Inferred from Sequence Orthology more info
involved_in protein export from nucleus	ISS Inferred from Sequence or Structural Similarity more info
NOT involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of intracellular protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of intracellular protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
part_of serine/threonine protein kinase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of serine/threonine protein kinase complex	IEA Inferred from Electronic Annotation more info
part_of serine/threonine protein kinase complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: STE20-related kinase adapter protein alpha

Names: STE20-related adapter protein; STE20-related kinase adaptor alpha; STRAD alpha; protein kinase LYK5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001415111.1 → NP_001402040.1 STE20-related kinase adapter protein alpha isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

A6HK11
NM_001415112.1 → NP_001402041.1 STE20-related kinase adapter protein alpha isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

A0A8I5ZXZ5, A6HK12
NM_001415113.1 → NP_001402042.1 STE20-related kinase adapter protein alpha isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

A0A8I5ZXZ5, A6HK12
NM_182820.3 → NP_877972.2 STE20-related kinase adapter protein alpha isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

Q66HD4, Q7TNZ6

UniProtKB/TrEMBL

A6HK10

Related

ENSRNOP00000081722.1, ENSRNOT00000119526.2

Conserved Domains (1) summary

cd08227
Location:33 → 359

PK_STRAD_alpha; Pseudokinase domain of STE20-related kinase adapter protein alpha

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

91594648..91623710 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063269203.1 → XP_063125273.1 STE20-related kinase adapter protein alpha isoform X7
XM_063269204.1 → XP_063125274.1 STE20-related kinase adapter protein alpha isoform X9
XM_008768362.3 → XP_008766584.1 STE20-related kinase adapter protein alpha isoform X8

UniProtKB/Swiss-Prot

Q66HD4, Q7TNZ6

Conserved Domains (2) summary

smart00220
Location:32 → 342

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl21453
Location:33 → 365

PKc_like; Protein Kinases, catalytic domain
XM_039086166.2 → XP_038942094.1 STE20-related kinase adapter protein alpha isoform X5

UniProtKB/TrEMBL

A0A8I6GKR2, F1M341

Conserved Domains (1) summary

cd08227
Location:62 → 388

PK_STRAD_alpha; Pseudokinase domain of STE20-related kinase adapter protein alpha
XM_063269202.1 → XP_063125272.1 STE20-related kinase adapter protein alpha isoform X4
XM_008768360.3 → XP_008766582.1 STE20-related kinase adapter protein alpha isoform X3

UniProtKB/TrEMBL

F1M341

Conserved Domains (2) summary

smart00220
Location:61 → 371

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl21453
Location:62 → 394

PKc_like; Protein Kinases, catalytic domain
XM_063269205.1 → XP_063125275.1 STE20-related kinase adapter protein alpha isoform X10

UniProtKB/TrEMBL

G3V9L2

Related

ENSRNOP00000051998.5, ENSRNOT00000055125.6
XM_008768361.3 → XP_008766583.1 STE20-related kinase adapter protein alpha isoform X6

UniProtKB/TrEMBL

F1M341

Conserved Domains (2) summary

smart00220
Location:40 → 350

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl21453
Location:41 → 373

PKc_like; Protein Kinases, catalytic domain
XM_006247586.4 → XP_006247648.1 STE20-related kinase adapter protein alpha isoform X2

UniProtKB/TrEMBL

F1M341

Related

ENSRNOP00000094426.2, ENSRNOT00000094696.2

Conserved Domains (2) summary

smart00220
Location:69 → 379

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl21453
Location:70 → 401

PKc_like; Protein Kinases, catalytic domain
XM_008768359.3 → XP_008766581.1 STE20-related kinase adapter protein alpha isoform X1

UniProtKB/TrEMBL

F1M341

Conserved Domains (2) summary

smart00220
Location:69 → 379

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl21453
Location:70 → 402

PKc_like; Protein Kinases, catalytic domain
XM_039086167.2 → XP_038942095.1 STE20-related kinase adapter protein alpha isoform X11

UniProtKB/TrEMBL

F1M341

Conserved Domains (1) summary

cl21453
Location:12 → 344

PKc_like; Protein Kinases, catalytic domain
XM_008768364.3 → XP_008766586.1 STE20-related kinase adapter protein alpha isoform X11

See identical proteins and their annotated locations for XP_008766586.1

UniProtKB/TrEMBL

F1M341

Conserved Domains (1) summary

cl21453
Location:12 → 344

PKc_like; Protein Kinases, catalytic domain
XM_063269206.1 → XP_063125276.1 STE20-related kinase adapter protein alpha isoform X11
XM_063269207.1 → XP_063125277.1 STE20-related kinase adapter protein alpha isoform X12