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    Map3k19 mitogen-activated protein kinase kinase kinase 19 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289001, updated on 27-Dec-2024

    Summary

    Symbol
    Map3k19provided by RGD
    Full Name
    mitogen-activated protein kinase kinase kinase 19provided by RGD
    Primary source
    RGD:1566400
    See related
    EnsemblRapid:ENSRNOG00000003952 AllianceGenome:RGD:1566400
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ysk4; RGD1566400; AABR07020879.1
    Summary
    Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Predicted to be involved in MAPK cascade. Orthologous to human MAP3K19 (mitogen-activated protein kinase kinase kinase 19). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 18.0), Brain (RPKM 4.2) and 2 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Map3k19 in Genome Data Viewer
    Location:
    13q13
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (41852633..41896078, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (39300150..39343502, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (44524055..44553197, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene aminocarboxymuconate semialdehyde decarboxylase Neighboring gene cyclin T2 Neighboring gene small nucleolar RNA SNORA36 family Neighboring gene RAB3 GTPase activating protein catalytic subunit 1 Neighboring gene zinc finger RANBP2-type containing 3 Neighboring gene microRNA 3473

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    mitogen-activated protein kinase kinase kinase 19
    Names
    YSK4 Sps1/Ste20-related kinase homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      41852633..41896078 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039091284.2XP_038947212.1  mitogen-activated protein kinase kinase kinase 19

      UniProtKB/TrEMBL
      F1LVM0
      Related
      ENSRNOP00000005244.8, ENSRNOT00000005244.8
      Conserved Domains (2) summary
      cd06631
      Location:12441509
      STKc_YSK4; Catalytic domain of the Serine/Threonine Kinase, Yeast Sps1/Ste20-related Kinase 4
      sd00045
      Location:4474
      ANK; ANK repeat [structural motif]

    RNA

    1. XR_010056991.1 RNA Sequence