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    Ddx17 DEAD-box helicase 17 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315133, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Ddx17provided by RGD
    Official Full Name
    DEAD-box helicase 17provided by RGD
    Primary source
    RGD:1304945
    See related
    EnsemblRapid:ENSRNOG00000051170 AllianceGenome:RGD:1304945
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable RNA helicase activity; nucleic acid binding activity; and transcription coactivator activity. Predicted to be involved in several processes, including RNA metabolic process; nuclear receptor-mediated steroid hormone signaling pathway; and regulation of RNA metabolic process. Predicted to be located in nuclear speck. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human DDX17 (DEAD-box helicase 17). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 1158.2), Lung (RPKM 966.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ddx17 in Genome Data Viewer
    Location:
    7q34
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (112971522..112989747, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (111091127..111109353, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (120761843..120765012, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 4 Neighboring gene KDEL endoplasmic reticulum protein retention receptor 3 Neighboring gene DNA meiotic recombinase 1 Neighboring gene family with sequence similarity 227, member A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The Ddx5 and Ddx17 RNA helicases are cornerstones in the complex regulatory array of steroid hormone-signaling pathways. Samaan S, et al. Nucleic Acids Res, 2014 Feb. PMID 24275493, Free PMC Article
    2. Myogenin promoter-associated lncRNA Myoparr is essential for myogenic differentiation. Hitachi K, et al. EMBO Rep, 2019 Mar. PMID 30622218, Free PMC Article
    3. The miRNA biogenesis factors, p72/DDX17 and KHSRP regulate the protein level of Ago2 in human cells. Connerty P, et al. Biochim Biophys Acta, 2016 Oct. PMID 27478153
    4. Concerted activation of the Mdm2 promoter by p72 RNA helicase and the coactivators p300 and P/CAF. Shin S, et al. J Cell Biochem, 2007 Aug 1. PMID 17226766
    5. RNA helicases DDX5 and DDX17 dynamically orchestrate transcription, miRNA, and splicing programs in cell differentiation. Dardenne E, et al. Cell Rep, 2014 Jun 26. PMID 24910439

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC109323

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lncRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in alternative mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in alternative mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in androgen receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in estrogen receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in miRNA metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in miRNA transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in myoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of skeletal muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    probable ATP-dependent RNA helicase DDX17
    Names
    DEAD (Asp-Glu-Ala-Asp) box helicase 17
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 17
    NP_001015018.1
    NP_001359065.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001015018.2 → NP_001015018.1  probable ATP-dependent RNA helicase DDX17 isoform 2

      See identical proteins and their annotated locations for NP_001015018.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains a distinct 5' UTR and lacks most of the exons in the coding region, compared to transcript variant 1. The resulting protein (isoform 2) is much shorter with a different N-terminus when compared to isoform 1.
      Source sequence(s)
      FQ236955, JAXUCZ010000007
      UniProtKB/TrEMBL
      A6HSS5, Q568Z8
      Conserved Domains (1) summary
      PTZ00110
      Location:22 → 118
      PTZ00110; helicase; Provisional

    2. NM_001372136.1 → NP_001359065.1  probable ATP-dependent RNA helicase DDX17 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      FQ236955, JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A096MIX2, A6HSS3, E9PT29
      Related
      ENSRNOP00000018185.8, ENSRNOT00000018185.9
      Conserved Domains (1) summary
      PTZ00110
      Location:32 → 502
      PTZ00110; helicase; Provisional

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      112971522..112989747 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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