Cbln2 cerebellin 2 precursor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cbln2provided by RGD
Official Full Name: cerebellin 2 precursorprovided by RGD
Primary source: RGD:1309715
See related: EnsemblRapid:ENSRNOG00000013654 AllianceGenome:RGD:1309715
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to be involved in maintenance of synapse structure; spontaneous synaptic transmission; and trans-synaptic signaling, modulating synaptic transmission. Predicted to act upstream of or within positive regulation of synapse assembly. Predicted to be located in extracellular space. Predicted to be part of trans-synaptic protein complex. Predicted to be active in glutamatergic synapse and synaptic cleft. Orthologous to human CBLN2 (cerebellin 2 precursor). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 71.5), Spleen (RPKM 15.9) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 18q13

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (82215210..82222648)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (79940412..79948766)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (83775568..83783841)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cerebellin-2 promotes endothelial-mesenchymal transition in hypoxic pulmonary hypertension rats by activating NF-kappaB/HIF-1alpha/Twist1 pathway.
Title: Cerebellin-2 promotes endothelial-mesenchymal transition in hypoxic pulmonary hypertension rats by activating NF-κB/HIF-1α/Twist1 pathway.
Findings demonstrate that hippocampal synapse assembly and maintenance require a tripartite molecular complex in which the ligand Cbln2 binds with presynaptic neurexin 1beta (+S4) and postsynaptic GluD1.
Title: Postsynaptic δ1 glutamate receptor assembles and maintains hippocampal synapses via Cbln2 and neurexin.

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General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in maintenance of synapse structure	IBA Inferred from Biological aspect of Ancestor more info
involved_in maintenance of synapse structure	ISO Inferred from Sequence Orthology more info
involved_in maintenance of synapse structure	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of synapse assembly	ISO Inferred from Sequence Orthology more info
involved_in spontaneous synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in spontaneous synaptic transmission	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of synapse assembly	ISO Inferred from Sequence Orthology more info
involved_in synapse organization	ISO Inferred from Sequence Orthology more info
involved_in synapse organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in trans-synaptic signaling, modulating synaptic transmission	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
is_active_in synaptic cleft	ISO Inferred from Sequence Orthology more info
located_in synaptic cleft	ISO Inferred from Sequence Orthology more info
part_of trans-synaptic protein complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cerebellin-2

Names: cerebellin 2 precursor protein; cerebellin-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.