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    Plch1 phospholipase C, eta 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 310463, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Plch1provided by RGD
    Official Full Name
    phospholipase C, eta 1provided by RGD
    Primary source
    RGD:1561991
    See related
    EnsemblRapid:ENSRNOG00000009955 AllianceGenome:RGD:1561991
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Plcl3; RGD1561991
    Summary
    Predicted to enable calcium-dependent phospholipase C activity and phosphatidylinositol phospholipase C activity. Predicted to be involved in phosphatidylinositol metabolic process; phosphatidylinositol-mediated signaling; and release of sequestered calcium ion into cytosol. Predicted to be located in cytosol; intracellular membrane-bounded organelle; and membrane. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in holoprosencephaly. Orthologous to human PLCH1 (phospholipase C eta 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 34.1), Brain (RPKM 28.4) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Plch1 in Genome Data Viewer
    Location:
    2q31
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (150298547..150514120, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (148148908..148363616, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (154256382..154468166, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene fission, mitochondrial 1, pseudogene 1 Neighboring gene similar to human chromosome 3 open reading frame 33 Neighboring gene solute carrier family 33 member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and characterization of a novel phospholipase C, PLC-eta. Hwang JI, et al. Biochem J, 2005 Jul 1. PMID 15702972, Free PMC Article
    2. The novel testicular enrichment protein Cfap58 is required for Notch-associated ciliogenesis. Li ZZ, et al. Biosci Rep, 2020 Jan 31. PMID 31904090, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium-dependent phospholipase C activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol phospholipase C activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylinositol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylinositol-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphatidylinositol-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in release of sequestered calcium ion into cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1
    Names
    phospholipase C-like 3
    NP_001178636.1
    XP_038958212.1
    XP_063137859.1
    XP_063137860.1
    XP_063137861.1
    XP_063137862.1
    XP_063137863.1
    XP_063137864.1
    XP_063137865.1
    XP_063137866.1
    XP_063137867.1
    XP_063137868.1
    XP_063137869.1
    XP_063137870.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191707.1 → NP_001178636.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A096MJ91, D4A4H0
      Related
      ENSRNOP00000068040.3, ENSRNOT00000076326.3
      Conserved Domains (6) summary
      cd00275
      Location:713 → 837
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08632
      Location:280 → 683
      PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
      cd00051
      Location:128 → 194
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam09279
      Location:209 → 280
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
      pfam13499
      Location:129 → 190
      EF-hand_7; EF-hand domain pair
      cl17171
      Location:4 → 110
      PH-like; Pleckstrin homology-like domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      150298547..150514120 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063281791.1 → XP_063137861.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X1

    2. XM_063281797.1 → XP_063137867.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X7

    3. XM_063281796.1 → XP_063137866.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X6

    4. XM_063281792.1 → XP_063137862.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X2

    5. XM_063281795.1 → XP_063137865.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X5

    6. XM_063281793.1 → XP_063137863.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X3

    7. XM_063281789.1 → XP_063137859.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X1

    8. XM_063281790.1 → XP_063137860.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X1

    9. XM_063281794.1 → XP_063137864.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X4

    10. XM_039102284.2 → XP_038958212.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X11

      Conserved Domains (1) summary
      cd00275
      Location:10 → 99
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)

    11. XM_063281799.1 → XP_063137869.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X9

    12. XM_063281798.1 → XP_063137868.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X8

    13. XM_063281800.1 → XP_063137870.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X10

      Related
      ENSRNOP00000068291.3, ENSRNOT00000076165.4
    Nucleotide Protein Strain
    Heading Accession and Version

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