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    Ebi3 Epstein-Barr virus induced 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 680609, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Ebi3provided by RGD
    Official Full Name
    Epstein-Barr virus induced 3provided by RGD
    Primary source
    RGD:1589467
    See related
    EnsemblRapid:ENSRNOG00000050509 AllianceGenome:RGD:1589467
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable cytokine receptor activity and interleukin-27 receptor binding activity. Predicted to be involved in T cell proliferation. Biomarker of pre-eclampsia. Orthologous to human EBI3 (Epstein-Barr virus induced 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 23.8), Thymus (RPKM 6.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ebi3 in Genome Data Viewer
    Location:
    9q11
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (861441..874731)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (774252..787544)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (11110874..11114843, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S8, pseudogene 14 Neighboring gene UDP-glucuronate decarboxylase 1 Neighboring gene zinc finger protein 119b like Neighboring gene small nucleolar RNA SNORA48 Neighboring gene ribosomal protein S21, pseudogene 2 Neighboring gene uncharacterized LOC134480467 Neighboring gene YJU2 splicing factor Neighboring gene src homology 2 domain-containing transforming protein D

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. EBI3 deficiency leads to diminished T helper type 1 and increased T helper type 2 mediated airway inflammation. Dokmeci E, et al. Immunology, 2011 Apr. PMID 21255010, Free PMC Article
    2. The effect of interleukins 27 and 35 and their role on mediating the action of insulin Like Growth Factor -1 on the inflammation and blood flow of chronically inflamed rat knee joint. Houshmandi N, et al. Cytokine, 2016 May. PMID 26994309
    3. Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin. Devergne O, et al. Proc Natl Acad Sci U S A, 1997 Oct 28. PMID 9342359, Free PMC Article
    4. Metformin exhibits its therapeutic effect in the treatment of pre-eclampsia via modulating the Met/H19/miR-148a-5p/P28 and Met/H19/miR-216-3p/EBI3 signaling pathways. Shu C, et al. Int Immunopharmacol, 2019 Sep. PMID 31203154
    5. IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells. Pflanz S, et al. Immunity, 2002 Jun. PMID 12121660

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that endogenous interleukins IL-27 and IL-35 (Ebi3 and Il-12p35 subunits) had inflammatory roles and insulin like growth factor -1 (IGF-1) had no effect.
      Title: The effect of interleukins 27 and 35 and their role on mediating the action of insulin Like Growth Factor -1 on the inflammation and blood flow of chronically inflamed rat knee joint.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cytokine receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables interleukin-27 receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    interleukin-27 subunit beta
    Names
    Epstein-Barr virus induced gene 3 (similar to Interleukin-27 beta chain precursor)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109421.2 → NP_001102891.1  interleukin-27 subunit beta precursor

      See identical proteins and their annotated locations for NP_001102891.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A6KR24, M0RD76
      Related
      ENSRNOP00000067573.1, ENSRNOT00000072031.3
      Conserved Domains (1) summary
      cd00063
      Location:128 → 216
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      861441..874731
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063267725.1 → XP_063123795.1  interleukin-27 subunit beta isoform X1

    2. XM_039084203.1 → XP_038940131.1  interleukin-27 subunit beta isoform X2

      Conserved Domains (1) summary
      cd00063
      Location:34 → 122
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    Nucleotide Protein Strain
    Heading Accession and Version

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