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    Fam76b family with sequence similarity 76, member B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 367021, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Fam76bprovided by RGD
    Official Full Name
    family with sequence similarity 76, member Bprovided by RGD
    Primary source
    RGD:1311077
    See related
    EnsemblRapid:ENSRNOG00000024863 AllianceGenome:RGD:1311077
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1311077
    Summary
    Predicted to be involved in several processes, including mRNA stabilization; negative regulation of macrophage activation; and negative regulation of protein export from nucleus. Predicted to be active in nuclear speck. Orthologous to human FAM76B (family with sequence similarity 76 member B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 157.9), Spleen (RPKM 118.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fam76b in Genome Data Viewer
    Location:
    8q12
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (18971357..18993442)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (10689396..10711847)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (12355767..12378040)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene myotubularin related protein 2 Neighboring gene centrosomal protein 57 Neighboring gene uncharacterized LOC134480141 Neighboring gene uncharacterized LOC134480142 Neighboring gene uncharacterized LOC103693014

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Genome-wide analysis of histidine repeats reveals their role in the localization of human proteins to the nuclear speckles compartment. Salichs E, et al. PLoS Genet, 2009 Mar. PMID 19266028, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in mRNA stabilization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of macrophage activation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of macrophage activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein export from nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of protein export from nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nuclear speck IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein FAM76B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001394343.1 → NP_001381272.1  protein FAM76B isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I6GJF8
      Conserved Domains (1) summary
      pfam16046
      Location:6 → 327
      FAM76; FAM76 protein

    2. NM_001401220.1 → NP_001388149.1  protein FAM76B isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I6GG35, A0A8I6GJF8, A6JN80
      Related
      ENSRNOP00000087548.1, ENSRNOT00000116723.2

    RNA

    1. NR_172100.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      18971357..18993442
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006242526.3 → XP_006242588.1  protein FAM76B isoform X1

      UniProtKB/TrEMBL
      A0A8I6AI20, A0A8I6GJF8
      Related
      ENSRNOP00000092636.1, ENSRNOT00000110705.2
      Conserved Domains (1) summary
      pfam16046
      Location:6 → 311
      FAM76; FAM76 protein

    2. XM_006242527.3 → XP_006242589.1  protein FAM76B isoform X2

      UniProtKB/TrEMBL
      A0A8I6GJF8
      Conserved Domains (1) summary
      pfam16046
      Location:6 → 310
      FAM76; FAM76 protein

    3. XM_039081825.2 → XP_038937753.1  protein FAM76B isoform X3

      UniProtKB/TrEMBL
      A0A8I6GJF8
      Related
      ENSRNOP00000105068.1, ENSRNOT00000123240.1
      Conserved Domains (1) summary
      pfam16046
      Location:6 → 311
      FAM76; FAM76 protein

    4. XM_039081826.2 → XP_038937754.1  protein FAM76B isoform X4

      UniProtKB/TrEMBL
      A0A8I6GJF8
      Conserved Domains (1) summary
      pfam16046
      Location:6 → 310
      FAM76; FAM76 protein

    5. XM_039081829.2 → XP_038937757.1  protein FAM76B isoform X7

      UniProtKB/TrEMBL
      A6JN81, D3Z8B9
      Conserved Domains (1) summary
      pfam16046
      Location:6 → 147
      FAM76; FAM76 protein

    6. XM_006242531.5 → XP_006242593.1  protein FAM76B isoform X5

      Conserved Domains (1) summary
      pfam16046
      Location:145 → 266
      FAM76; FAM76 protein

    7. XM_039081827.2 → XP_038937755.1  protein FAM76B isoform X6

      Conserved Domains (1) summary
      pfam16046
      Location:101 → 222
      FAM76; FAM76 protein

    RNA

    1. XR_010054004.1 RNA Sequence

    2. XR_010054005.1 RNA Sequence

    3. XR_010054003.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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