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    Ecpas Ecm29 proteasome adaptor and scaffold [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313196, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Ecpasprovided by RGD
    Official Full Name
    Ecm29 proteasome adaptor and scaffoldprovided by RGD
    Primary source
    RGD:1306148
    See related
    EnsemblRapid:ENSRNOG00000025076 AllianceGenome:RGD:1306148
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1306148
    Summary
    Predicted to enable molecular adaptor activity and proteasome binding activity. Predicted to be involved in ERAD pathway. Predicted to be located in several cellular components, including centrosome; cytoplasmic vesicle; and nucleoplasm. Predicted to be part of proteasome complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human ECPAS (Ecm29 proteasome adaptor and scaffold). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 900.1), Heart (RPKM 373.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ecpas in Genome Data Viewer
    Location:
    5q24
    Exon count:
    51
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (78398449..78509077, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (73601745..73714026, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (75928510..76040771, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene brain expressed, X-linked 1, pseudogene 1 Neighboring gene olfactory receptor family 2 subfamily K member 2 Neighboring gene NADH:ubiquinone oxidoreductase subunit A5, pseudogene 4 Neighboring gene heat shock protein family D (Hsp60) member 1, pseudogene 10 Neighboring gene chaperonin containing Tcp1, subunit 6A (zeta 1), pseudogene 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Characterization of mammalian Ecm29, a 26 S proteasome-associated protein that localizes to the nucleus and membrane vesicles. Gorbea C, et al. J Biol Chem, 2004 Dec 24. PMID 15496406
    2. A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components. Gorbea C, et al. J Biol Chem, 2010 Oct 8. PMID 20682791, Free PMC Article
    3. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular adaptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables proteasome binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasome assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in COPII-coated ER to Golgi transport vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in late endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in multivesicular body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of proteasome complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    Ecm29 proteasome adaptor and scaffold; proteasome adapter and scaffold protein ECM29

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001431167.1 → NP_001418096.1  Ecm29 proteasome adaptor and scaffold isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A8I6A123, A0A8I6AH81

    2. NM_001431168.1 → NP_001418097.1  Ecm29 proteasome adaptor and scaffold isoform b

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A8I6A123

    3. NM_001431169.1 → NP_001418098.1  Ecm29 proteasome adaptor and scaffold isoform c

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A8I6A123

    4. NM_001431170.1 → NP_001418099.1  Ecm29 proteasome adaptor and scaffold isoform c

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A8I6A123

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      78398449..78509077 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_056985549.2 → XP_056841529.1  proteasome adapter and scaffold protein ECM29 isoform X2

      Related
      ENSRNOP00000080633.2, ENSRNOT00000119799.2

    2. XM_056985548.2 → XP_056841528.1  proteasome adapter and scaffold protein ECM29 isoform X3

      Related
      ENSRNOP00000093368.2, ENSRNOT00000112613.2

    3. XM_056985546.2 → XP_056841526.1  proteasome adapter and scaffold protein ECM29 isoform X1

      Related
      ENSRNOP00000092109.1, ENSRNOT00000105222.2

    4. XM_056985550.2 → XP_056841530.1  proteasome adapter and scaffold protein ECM29 isoform X4

      UniProtKB/TrEMBL
      A0A8I6A123
      Related
      ENSRNOP00000099661.1, ENSRNOT00000163150.1
    Nucleotide Protein Strain
    Heading Accession and Version

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