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    Dhrsx dehydrogenase/reductase X-linked [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288525, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dhrsxprovided by RGD
    Official Full Name
    dehydrogenase/reductase X-linkedprovided by RGD
    Primary source
    RGD:1305017
    See related
    EnsemblRapid:ENSRNOG00000028323 AllianceGenome:RGD:1305017
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable oxidoreductase activity. Predicted to be involved in positive regulation of autophagy. Predicted to be active in extracellular region. Orthologous to human DHRSX (dehydrogenase/reductase X-linked). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 105.2), Thymus (RPKM 94.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dhrsx in Genome Data Viewer
    Location:
    12q11
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (21413563..21418319)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (16299768..16304553)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (18516858..18521235)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 157 Neighboring gene uncharacterized LOC134481271 Neighboring gene olfactory receptor family 7 subfamily A member 43, pseudogene 1 Neighboring gene acetylserotonin O-methyltransferase Neighboring gene A-kinase anchoring protein 17A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. DHRSX, a novel non-classical secretory protein associated with starvation induced autophagy. Zhang G, et al. Int J Med Sci, 2014. PMID 25076851, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables dolichal reductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables polyprenol dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in dolichol biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of autophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in lipid droplet ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    dehydrogenase/reductase SDR family member on chromosome X
    Names
    dehydrogenase/reductase (SDR family) X chromosome
    dehydrogenase/reductase (SDR family) X-linked

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105914.2 → NP_001099384.2  dehydrogenase/reductase SDR family member on chromosome X isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      A6K200

    2. NM_001400919.1 → NP_001387848.1  dehydrogenase/reductase SDR family member on chromosome X isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      A0A8J8YGQ6, B2RZ76, E9PTT7
      Related
      ENSRNOP00000031241.7, ENSRNOT00000029485.8

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      21413563..21418319
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006248995.5 → XP_006249057.1  dehydrogenase/reductase SDR family member on chromosome X isoform X2

      Conserved Domains (1) summary
      cl21454
      Location:41 → 187
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    2. XM_039089192.2 → XP_038945120.1  dehydrogenase/reductase SDR family member on chromosome X isoform X4

      Conserved Domains (1) summary
      cl21454
      Location:41 → 187
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    3. XM_017598292.3 → XP_017453781.1  dehydrogenase/reductase SDR family member on chromosome X isoform X1

      UniProtKB/TrEMBL
      B2RZ76, E9PTT7

    4. XM_063271142.1 → XP_063127212.1  dehydrogenase/reductase SDR family member on chromosome X isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

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