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    Colgalt1 collagen beta(1-O)galactosyltransferase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 290637, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Colgalt1provided by RGD
    Official Full Name
    collagen beta(1-O)galactosyltransferase 1provided by RGD
    Primary source
    RGD:1309002
    See related
    EnsemblRapid:ENSRNOG00000023317 AllianceGenome:RGD:1309002
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Glt25d1; RGD1309002
    Summary
    Predicted to enable procollagen galactosyltransferase activity. Predicted to be involved in positive regulation of collagen fibril organization. Predicted to be located in endoplasmic reticulum lumen. Human ortholog(s) of this gene implicated in brain small vessel disease 3. Orthologous to human COLGALT1 (collagen beta(1-O)galactosyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 213.7), Lung (RPKM 195.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Colgalt1 in Genome Data Viewer
    Location:
    16p14
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (18353779..18366087)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (18319796..18332106)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (20039969..20052277)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 27 member 1 Neighboring gene 6-phosphogluconolactonase Neighboring gene niban apoptosis regulator 3 Neighboring gene unc-13 homolog A Neighboring gene Janus kinase 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Collagen Accumulation in Osteosarcoma Cells lacking GLT25D1 Collagen Galactosyltransferase. Baumann S, et al. J Biol Chem, 2016 Aug 26. PMID 27402836, Free PMC Article
    2. The human collagen beta(1-O)galactosyltransferase, GLT25D1, is a soluble endoplasmic reticulum localized protein. Liefhebber JM, et al. BMC Cell Biol, 2010 May 14. PMID 20470363, Free PMC Article
    3. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables procollagen galactosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of collagen fibril organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum lumen ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    procollagen galactosyltransferase 1
    Names
    glycosyltransferase 25 domain containing 1
    NP_001099537.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106067.2 → NP_001099537.1  procollagen galactosyltransferase 1 precursor

      See identical proteins and their annotated locations for NP_001099537.1

      Status: PROVISIONAL

      Source sequence(s)
      BC160899
      UniProtKB/TrEMBL
      A6K9X0, B1H282, F6T463
      Related
      ENSRNOP00000024866.4, ENSRNOT00000024866.7
      Conserved Domains (2) summary
      pfam01755
      Location:335 → 520
      Glyco_transf_25; Glycosyltransferase family 25 (LPS biosynthesis protein)
      pfam13704
      Location:56 → 170
      Glyco_tranf_2_4; Glycosyl transferase family 2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      18353779..18366087
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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