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    Rnf180 ring finger protein 180 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 685384, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Rnf180provided by RGD
    Official Full Name
    ring finger protein 180provided by RGD
    Primary source
    RGD:1595064
    See related
    EnsemblRapid:ENSRNOG00000043329 AllianceGenome:RGD:1595064
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ubiquitin conjugating enzyme binding activity and ubiquitin protein ligase activity. Predicted to be involved in norepinephrine metabolic process; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; and serotonin metabolic process. Predicted to act upstream of or within several processes, including adult behavior; positive regulation of protein ubiquitination; and protein polyubiquitination. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human RNF180 (ring finger protein 180). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 24.6), Testes (RPKM 7.4) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rnf180 in Genome Data Viewer
    Location:
    2q13
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (38064026..38244854, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (36330285..36511168, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (35718100..35892578, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene regulator of G-protein signaling 7 binding protein Neighboring gene trifunctional nucleotide phosphoesterase protein YfkN-like Neighboring gene small nucleolar RNA SNORA17 Neighboring gene 5-hydroxytryptamine receptor 1A Neighboring gene ribosomal protein L17 like 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Rines E3 ubiquitin ligase regulates MAO-A levels and emotional responses. Kabayama M, et al. J Neurosci, 2013 Aug 7. PMID 23926250, Free PMC Article
    2. Rines/RNF180, a novel RING finger gene-encoded product, is a membrane-bound ubiquitin ligase. Ogawa M, et al. Genes Cells, 2008 Apr. PMID 18363970
    3. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC188174

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin conjugating enzyme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin conjugating enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within adult behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in norepinephrine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within norepinephrine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of catalytic activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in serotonin metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within serotonin metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase RNF180
    NP_001128458.1
    XP_038959062.2
    XP_038959064.1
    XP_063138620.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134986.2 → NP_001128458.1  E3 ubiquitin-protein ligase RNF180

      See identical proteins and their annotated locations for NP_001128458.1

      Status: VALIDATED

      Source sequence(s)
      BC168657
      UniProtKB/TrEMBL
      B5DEG2, F1LRQ3
      Related
      ENSRNOP00000083351.2, ENSRNOT00000112277.2
      Conserved Domains (1) summary
      cd00162
      Location:432 → 477
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      38064026..38244854 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063282550.1 → XP_063138620.1  E3 ubiquitin-protein ligase RNF180 isoform X2

      UniProtKB/TrEMBL
      F1LRQ3
      Related
      ENSRNOP00000104655.1, ENSRNOT00000145284.1

    2. XM_039103136.2 → XP_038959064.1  E3 ubiquitin-protein ligase RNF180 isoform X2

      UniProtKB/TrEMBL
      F1LRQ3
      Conserved Domains (1) summary
      cd16554
      Location:431 → 474
      RING-HC_RNF180; RING finger, HC subclass, found in RING finger protein 180 (RNF180) and similar proteins

    3. XM_039103134.2 → XP_038959062.2  E3 ubiquitin-protein ligase RNF180 isoform X1

      UniProtKB/TrEMBL
      B5DEG2, F1LRQ3
    Nucleotide Protein Strain
    Heading Accession and Version

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