Abcc5 ATP binding cassette subfamily C member 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Abcc5provided by RGD
Official Full Name: ATP binding cassette subfamily C member 5provided by RGD
Primary source: RGD:70913
See related: EnsemblRapid:ENSRNOG00000029178 AllianceGenome:RGD:70913
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Mrp5; Abcc5a
Summary: Predicted to enable several functions, including ABC-type xenobiotic transporter activity; glutathione transmembrane transporter activity; and heme transmembrane transporter activity. Involved in response to insulin and response to lipopolysaccharide. Located in basolateral plasma membrane and perinuclear region of cytoplasm. Orthologous to human ABCC5 (ATP binding cassette subfamily C member 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Adrenal (RPKM 1797.5), Brain (RPKM 177.4) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 11q23

Exon count:: 33

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (93975579..94071659)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (80473809..80567257)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (84395982..84490215)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Multidrug resistance-associated proteins 1, 4, 5, and Oatp1a4 were present at the transcript level, but only Mrp1, 4, and 5 were detected at the protein level.
Title: Identification and Functional Characterization of a GSH Conjugate Efflux Pathway in the Rat Lens.
In olfactory epithelium, high levels of expression of xenobiotic transporters Mrp1, Mrp3, Mrp5, Mdr1a, Oatp2 and Oat6 are expressed.
Title: Expression and differential localization of xenobiotic transporters in the rat olfactory neuro-epithelium.
important role for MRP5-mediated cGMP efflux in the regulation of NO-induced cerebral arteriolar relaxation
Title: Regulation of rat pial arteriolar smooth muscle relaxation in vivo through multidrug resistance protein 5-mediated cGMP efflux.
cyclic nucleotide cellular efflux plays a critical role in elimination of intracellular cGMP but not cAMP in pituitary cells and such selectivity is achieved by expression of MRP5
Title: Contribution of multidrug resistance protein MRP5 in control of cyclic guanosine 5'-monophosphate intracellular signaling in anterior pituitary cells.

Submit: New GeneRIF Correction

General gene information

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Markers

AI555746 (e-PCR)
- UniSTS:244044

RH143810 (e-PCR)
- UniSTS:233056

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ABC-type transporter activity	ISO Inferred from Sequence Orthology more info
enables ABC-type xenobiotic transporter activity	IEA Inferred from Electronic Annotation more info
enables ABC-type xenobiotic transporter activity	ISO Inferred from Sequence Orthology more info
enables ABC-type xenobiotic transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATPase-coupled transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATPase-coupled transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables carbohydrate derivative transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables carbohydrate derivative transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables efflux transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables efflux transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables glutathione transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables glutathione transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables heme transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables heme transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables heme transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables macromolecule transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables macromolecule transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables purine nucleotide transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables purine nucleotide transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables xenobiotic transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cAMP transport	IEA Inferred from Electronic Annotation more info
involved_in cAMP transport	ISO Inferred from Sequence Orthology more info
involved_in cGMP transport	IEA Inferred from Electronic Annotation more info
involved_in cGMP transport	ISO Inferred from Sequence Orthology more info
involved_in export across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in export across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in folate transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in folate transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in folate transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in glutathione transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in glutathione transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in heme transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in heme transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in heme transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in hyaluronan biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in hyaluronan biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in purine nucleotide transport	ISO Inferred from Sequence Orthology more info
involved_in response to insulin	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in xenobiotic transport	IEA Inferred from Electronic Annotation more info
involved_in xenobiotic transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi lumen	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in endosome membrane	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ATP-binding cassette sub-family C member 5

Names: ATP-binding cassette sub-family C (CFTR/MRP) member 5a; ATP-binding cassette, sub-family C (CFTR/MRP), member 5; ATP-binding cassette, sub-family C (CFTR/MRP), member 5a; ATP-binding cassette, subfamily C (CFTR/MRP), member 5; multidrug resistance-associated protein 5

XP_017453338.1

EC 7.6.2.2

XP_038943832.1

EC 7.6.2.2

XP_038943833.1

EC 7.6.2.2

XP_038943835.1

EC 7.6.2.2

XP_038943836.1

EC 7.6.2.2

XP_063126313.1

EC 7.6.2.2

XP_063126314.1

EC 7.6.2.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001433820.1 → NP_001420749.1 ATP-binding cassette sub-family C member 5 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000011
NM_001433821.1 → NP_001420750.1 ATP-binding cassette sub-family C member 5 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000011
NM_001433822.1 → NP_001420751.1 ATP-binding cassette sub-family C member 5 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000011
NM_001433823.1 → NP_001420752.1 ATP-binding cassette sub-family C member 5 isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000011
NM_001433824.1 → NP_001420753.1 ATP-binding cassette sub-family C member 5 isoform 4

Status: VALIDATED

Source sequence(s)

JAXUCZ010000011
NM_001433825.1 → NP_001420754.1 ATP-binding cassette sub-family C member 5 isoform 5

Status: VALIDATED

Source sequence(s)

JAXUCZ010000011
NM_001433826.1 → NP_001420755.1 ATP-binding cassette sub-family C member 5 isoform 5

Status: VALIDATED

Source sequence(s)

JAXUCZ010000011
NM_001433827.1 → NP_001420756.1 ATP-binding cassette sub-family C member 5 isoform 6

Status: VALIDATED

Source sequence(s)

JAXUCZ010000011
NM_001433828.1 → NP_001420757.1 ATP-binding cassette sub-family C member 5 isoform 7

Status: VALIDATED

Source sequence(s)

JAXUCZ010000011
NM_001433829.1 → NP_001420758.1 ATP-binding cassette sub-family C member 5 isoform 8

Status: VALIDATED

Source sequence(s)

JAXUCZ010000011
NM_001433830.1 → NP_001420759.1 ATP-binding cassette sub-family C member 5 isoform 8

Status: VALIDATED

Source sequence(s)

JAXUCZ010000011
NM_053924.2 → NP_446376.2 ATP-binding cassette sub-family C member 5 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000011

Related

ENSRNOP00000002316.7, ENSRNOT00000002316.9

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086029.1 Reference GRCr8

Range

93975579..94071659

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039087904.2 → XP_038943832.1 ATP-binding cassette sub-family C member 5 isoform X1

UniProtKB/Swiss-Prot

A0A0G2K6R4, Q9QYM0

UniProtKB/TrEMBL

A6JSB4, G3V676

Conserved Domains (1) summary

PLN03130
Location:100 → 1424

PLN03130; ABC transporter C family member; Provisional
XM_039087905.2 → XP_038943833.1 ATP-binding cassette sub-family C member 5 isoform X3

Conserved Domains (1) summary

cd18592
Location:181 → 467

ABC_6TM_MRP5_8_9_D1; Six-transmembrane helical domain 1 (TMD1) of multidrug resistance-associated proteins (MRPs) 5, 8, and 9
XM_039087908.2 → XP_038943836.1 ATP-binding cassette sub-family C member 5 isoform X5

UniProtKB/TrEMBL

A1A5M8, F7EV50

Related

ENSRNOP00000039986.6, ENSRNOT00000048306.7

Conserved Domains (1) summary

PLN03232
Location:100 → 156

PLN03232; ABC transporter C family member; Provisional
XM_063270244.1 → XP_063126314.1 ATP-binding cassette sub-family C member 5 isoform X4
XM_039087907.2 → XP_038943835.1 ATP-binding cassette sub-family C member 5 isoform X4

Conserved Domains (1) summary

PLN03232
Location:100 → 156

PLN03232; ABC transporter C family member; Provisional
XM_063270243.1 → XP_063126313.1 ATP-binding cassette sub-family C member 5 isoform X2
XM_017597849.3 → XP_017453338.1 ATP-binding cassette sub-family C member 5 isoform X2