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    Uxt ubiquitously-expressed, prefoldin-like chaperone [ Rattus norvegicus (Norway rat) ]

    Gene ID: 299313, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Uxtprovided by RGD
    Official Full Name
    ubiquitously-expressed, prefoldin-like chaperoneprovided by RGD
    Primary source
    RGD:1359326
    See related
    EnsemblRapid:ENSRNOG00000085857 AllianceGenome:RGD:1359326
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable beta-tubulin binding activity; chromatin binding activity; and transcription corepressor activity. Predicted to be involved in centrosome cycle and negative regulation of transcription by RNA polymerase II. Predicted to be located in several cellular components, including centrosome; chromatin; and nucleus. Predicted to be part of RPAP3/R2TP/prefoldin-like complex and mediator complex. Orthologous to human UXT (ubiquitously expressed prefoldin like chaperone). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 234.2), Kidney (RPKM 226.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Uxt in Genome Data Viewer
    Location:
    Xq11
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (3679630..3691944)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (1126110..1138670)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (1275402..1287781)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene sperm acrosome associated 5 Neighboring gene zinc finger protein 182 Neighboring gene zinc finger protein 81 Neighboring gene ETS transcription factor ELK1 Neighboring gene complement factor properdin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. UXT is a novel centrosomal protein essential for cell viability. Zhao H, et al. Mol Biol Cell, 2005 Dec. PMID 16221885, Free PMC Article
    2. Cloning and characterization of UXT, a novel gene in human Xp11, which is widely and abundantly expressed in tumor tissue. Schroer A, et al. Genomics, 1999 Mar 15. PMID 10087202
    3. Regulation of androgen receptor-mediated transcription by RPB5 binding protein URI/RMP. Mita P, et al. Mol Cell Biol, 2011 Sep. PMID 21730289, Free PMC Article
    4. Novel complex integrating mitochondria and the microtubular cytoskeleton with chromosome remodeling and tumor suppressor RASSF1 deduced by in silico homology analysis, interaction cloning in yeast, and colocalization in cultured cells. Liu L, et al. In Vitro Cell Dev Biol Anim, 2002 Nov-Dec. PMID 12762840, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC105797

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    NOT enables actin filament binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables beta-tubulin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables beta-tubulin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription corepressor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in centrosome cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in centrosome cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in microtubule cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of RPAP3/R2TP/prefoldin-like complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in spindle pole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein UXT
    Names
    ubiquitously expressed transcript protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001006982.1 → NP_001006983.1  protein UXT

      See identical proteins and their annotated locations for NP_001006983.1

      Status: PROVISIONAL

      Source sequence(s)
      BC082752
      UniProtKB/Swiss-Prot
      Q63ZY7
      UniProtKB/TrEMBL
      A6JZQ2
      Conserved Domains (1) summary
      cd00584
      Location:18 → 147
      Prefoldin_alpha; Prefoldin alpha subunit; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      3679630..3691944
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006256611.5 → XP_006256673.1  protein UXT isoform X2

      See identical proteins and their annotated locations for XP_006256673.1

      UniProtKB/Swiss-Prot
      Q63ZY7
      UniProtKB/TrEMBL
      A6JZQ2
      Related
      ENSRNOP00000102474.1, ENSRNOT00000145926.1
      Conserved Domains (1) summary
      cd00584
      Location:18 → 147
      Prefoldin_alpha; Prefoldin alpha subunit; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta ...

    2. XM_063279882.1 → XP_063135952.1  protein UXT isoform X1

    3. XM_063279881.1 → XP_063135951.1  protein UXT isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q63ZY7.1 GenPept UniProtKB/Swiss-Prot:Q63ZY7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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