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    Lhpp phospholysine phosphohistidine inorganic pyrophosphate phosphatase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361663, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Lhppprovided by RGD
    Official Full Name
    phospholysine phosphohistidine inorganic pyrophosphate phosphataseprovided by RGD
    Primary source
    RGD:1359187
    See related
    EnsemblRapid:ENSRNOG00000017097 AllianceGenome:RGD:1359187
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable inorganic diphosphate phosphatase activity; phosphatase activity; and protein homodimerization activity. Predicted to be involved in phosphate-containing compound metabolic process. Predicted to be located in nuclear speck. Predicted to be active in cytosol. Orthologous to human LHPP (phospholysine phosphohistidine inorganic pyrophosphate phosphatase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 80.3), Liver (RPKM 61.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Lhpp in Genome Data Viewer
    Location:
    1q41
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (196833516..196924687)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (187403390..187494577)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (204617804..204708987)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene ornithine aminotransferase Neighboring gene NK1 homeobox 2 Neighboring gene uncharacterized LOC120099944 Neighboring gene uncharacterized LOC120099945 Neighboring gene family with sequence similarity 53, member B Neighboring gene uncharacterized LOC134483949 Neighboring gene EEF1A lysine methyltransferase 2 Neighboring gene uncharacterized LOC102552031

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Expression of new human inorganic pyrophosphatase in thyroid diseases: its intimate association with hyperthyroidism. Koike E, et al. Biochem Biophys Res Commun, 2006 Mar 17. PMID 16430861
    2. Molecular cloning of a cDNA for the human phospholysine phosphohistidine inorganic pyrophosphate phosphatase. Yokoi F, et al. J Biochem, 2003 May. PMID 12801912
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC95092

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables inorganic diphosphate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables inorganic diphosphate phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inorganic diphosphate phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables inorganic diphosphate phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in phosphate-containing compound metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphate-containing compound metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphate-containing compound metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    phospholysine phosphohistidine inorganic pyrophosphate phosphatase
    NP_001009706.1
    XP_063123970.1
    XP_063123973.1
    XP_063123974.1
    XP_063123975.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009706.1 → NP_001009706.1  phospholysine phosphohistidine inorganic pyrophosphate phosphatase

      See identical proteins and their annotated locations for NP_001009706.1

      Status: PROVISIONAL

      Source sequence(s)
      BC088448
      UniProtKB/Swiss-Prot
      Q5I0D5
      UniProtKB/TrEMBL
      A0A8L2QD96
      Related
      ENSRNOP00000022971.5, ENSRNOT00000022971.5
      Conserved Domains (3) summary
      TIGR01458
      Location:11 → 267
      HAD-SF-IIA-hyp3; HAD-superfamily subfamily IIA hydrolase, TIGR01458
      pfam13242
      Location:186 → 260
      Hydrolase_like; HAD-hyrolase-like
      pfam13344
      Location:14 → 112
      Hydrolase_6; Haloacid dehalogenase-like hydrolase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      196833516..196924687
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063267904.1 → XP_063123974.1  phospholysine phosphohistidine inorganic pyrophosphate phosphatase isoform X3

    2. XM_063267900.1 → XP_063123970.1  phospholysine phosphohistidine inorganic pyrophosphate phosphatase isoform X1

      Related
      ENSRNOP00000103549.1, ENSRNOT00000130163.1

    3. XM_063267903.1 → XP_063123973.1  phospholysine phosphohistidine inorganic pyrophosphate phosphatase isoform X2

      Related
      ENSRNOP00000107655.1, ENSRNOT00000127562.1

    4. XM_063267905.1 → XP_063123975.1  phospholysine phosphohistidine inorganic pyrophosphate phosphatase isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5I0D5.1 GenPept UniProtKB/Swiss-Prot:Q5I0D5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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