Adprs ADP-ribosylserine hydrolase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Adprsprovided by RGD
Official Full Name: ADP-ribosylserine hydrolaseprovided by RGD
Primary source: RGD:1309068
See related: EnsemblRapid:ENSRNOG00000010849 AllianceGenome:RGD:1309068
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Adprhl2
Summary: Predicted to enable O-acetyl-ADP-ribose deacetylase activity; hydrolase activity, acting on glycosyl bonds; and magnesium ion binding activity. Predicted to be involved in DNA repair; negative regulation of necroptotic process; and peptidyl-serine ADP-deribosylation. Predicted to act upstream of or within cellular response to superoxide. Predicted to be located in cytoplasm; nuclear body; and site of DNA damage. Predicted to be active in mitochondrion and nucleus. Human ortholog(s) of this gene implicated in stress-induced childhood-onset neurodegeneration with variable ataxia and seizures. Orthologous to human ADPRS (ADP-ribosylserine hydrolase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 136.1), Spleen (RPKM 114.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (143898542..143903816, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (138614022..138619296, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (144336312..144341586, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ADP-ribosylserine hydrolase activity	ISO Inferred from Sequence Orthology more info
enables O-acetyl-ADP-ribose deacetylase activity	ISO Inferred from Sequence Orthology more info
enables hydrolase activity, hydrolyzing O-glycosyl compounds	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables poly(ADP-ribose) glycohydrolase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA repair	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to superoxide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to superoxide	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of necroptotic process	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-serine ADP-deribosylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in site of DNA damage	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ADP-ribosylhydrolase ARH3

Names: ADP-ribose glycohydrolase ARH3; ADP-ribosylhydrolase like 2; poly(ADP-ribose) glycohydrolase ARH3

NP_001102150.1

EC 3.2.1.143

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.