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    Ghitm growth hormone inducible transmembrane protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 290596, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Ghitmprovided by RGD
    Official Full Name
    growth hormone inducible transmembrane proteinprovided by RGD
    Primary source
    RGD:1359301
    See related
    EnsemblRapid:ENSRNOG00000013961 AllianceGenome:RGD:1359301
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    MICS1
    Summary
    Predicted to enable calcium channel activity and calcium:proton antiporter activity. Predicted to be involved in inner mitochondrial membrane organization; monoatomic cation transmembrane transport; and negative regulation of release of cytochrome c from mitochondria. Predicted to be located in endoplasmic reticulum membrane and mitochondrial membrane. Predicted to be active in mitochondrial inner membrane. Orthologous to human GHITM (growth hormone inducible transmembrane protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 1462.3), Adrenal (RPKM 1014.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ghitm in Genome Data Viewer
    Location:
    16p14
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (12907062..12918149, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (12885551..12897887, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (14370269..14382647, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 15 ligand Neighboring gene cytochrome c, somatic pseudogene Neighboring gene similar to human chromosome 14 open reading frame 119 Neighboring gene KICSTOR subunit 2, pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification, isolation, and cloning of growth hormone (GH)-inducible interscapular brown adipose complementary deoxyribonucleic acid from GH antagonist mice. Li Y, et al. Endocrinology, 2001 Jul. PMID 11416014
    2. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
    3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94737

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium:proton antiporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium:proton antiporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in calcium export from the mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium export from the mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in calcium export from the mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in calcium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in inner mitochondrial membrane organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in inner mitochondrial membrane organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in inner mitochondrial membrane organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitochondrial calcium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial calcium ion transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitochondrial potassium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial potassium ion transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of release of cytochrome c from mitochondria ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    growth hormone-inducible transmembrane protein
    Names
    mitochondrial morphology and cristae structure 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005908.1 → NP_001005908.1  growth hormone-inducible transmembrane protein

      See identical proteins and their annotated locations for NP_001005908.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083778
      UniProtKB/Swiss-Prot
      Q5XIA8
      UniProtKB/TrEMBL
      A0A8L2Q9B8, A6K9J5
      Conserved Domains (1) summary
      cd10431
      Location:82 → 345
      GHITM; Growth-hormone inducible transmembrane protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      12907062..12918149 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006252786.4 → XP_006252848.1  growth hormone-inducible transmembrane protein isoform X1

      See identical proteins and their annotated locations for XP_006252848.1

      UniProtKB/Swiss-Prot
      Q5XIA8
      UniProtKB/TrEMBL
      A0A8L2Q9B8, A6K9J5
      Related
      ENSRNOP00000077387.1, ENSRNOT00000106368.2
      Conserved Domains (1) summary
      cd10431
      Location:82 → 345
      GHITM; Growth-hormone inducible transmembrane protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XIA8.1 GenPept UniProtKB/Swiss-Prot:Q5XIA8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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