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    Psenen presenilin enhancer gamma secretase subunit [ Rattus norvegicus (Norway rat) ]

    Gene ID: 292788, updated on 27-Dec-2024

    Summary

    Official Symbol
    Psenenprovided by RGD
    Official Full Name
    presenilin enhancer gamma secretase subunitprovided by RGD
    Primary source
    RGD:1312037
    See related
    EnsemblRapid:ENSRNOG00000020941 AllianceGenome:RGD:1312037
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1312037
    Summary
    Predicted to enable endopeptidase activator activity and enzyme binding activity. Predicted to be involved in several processes, including amyloid-beta formation; positive regulation of endopeptidase activity; and proteolysis. Is active in presynaptic membrane. Human ortholog(s) of this gene implicated in hidradenitis suppurativa. Orthologous to human PSENEN (presenilin enhancer, gamma-secretase subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 340.6), Lung (RPKM 337.3) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Psenen in Genome Data Viewer
    Location:
    1q21
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (94942348..94943545, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (85814905..85816654, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (89016093..89017449, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene proline and serine rich 3 Neighboring gene heat shock protein family B (small) member 6 Neighboring gene lin-37 DREAM MuvB core complex component Neighboring gene U2 small nuclear RNA auxiliary factor 1-like 4 Neighboring gene IGF-like family receptor 1 Neighboring gene lysine methyltransferase 2B Neighboring gene microRNA 3569

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables endopeptidase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in Notch receptor processing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within Notch receptor processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in amyloid precursor protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in amyloid precursor protein metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in amyloid precursor protein metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in amyloid-beta formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in amyloid-beta formation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in membrane protein ectodomain proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in membrane protein intracellular domain proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein processing ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    part_of gamma-secretase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of gamma-secretase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of gamma-secretase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    gamma-secretase subunit PEN-2
    Names
    LRRGT00140 mRNA
    liver regeneration-related protein LRRGT00140
    presenilin enhancer 2 homolog
    presenilin enhancer protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008764.2NP_001008764.1  gamma-secretase subunit PEN-2

      See identical proteins and their annotated locations for NP_001008764.1

      Status: PROVISIONAL

      Source sequence(s)
      BC100104
      UniProtKB/Swiss-Prot
      Q6QI68
      UniProtKB/TrEMBL
      A6J9Z1
      Related
      ENSRNOP00000028438.3, ENSRNOT00000028438.6
      Conserved Domains (1) summary
      pfam10251
      Location:799
      PEN-2; Presenilin enhancer-2 subunit of gamma secretase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      94942348..94943545 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)