Psap prosaposin [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Psapprovided by RGD
Official Full Name: prosaposinprovided by RGD
Primary source: RGD:3423
See related: EnsemblRapid:ENSRNOG00000000571 AllianceGenome:RGD:3423
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: SGP-1; SGP1A
Summary: Predicted to enable several functions, including ganglioside binding activity; protein homodimerization activity; and scaffold protein binding activity. Predicted to be involved in several processes, including ganglioside GM1 transport to membrane; positive regulation of beta-galactosidase activity; and prostate gland development. Predicted to act upstream of or within with a negative effect on gene expression. Predicted to act upstream of or within several processes, including glycosylceramide metabolic process; nervous system development; and protein transport. Predicted to be located in aggresome; extracellular space; and late endosome. Predicted to be active in lysosome. Human ortholog(s) of this gene implicated in atypical Gaucher's disease due to saposin c deficiency; combined saposin deficiency; and late onset Parkinson's disease. Orthologous to human PSAP (prosaposin). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 4506.6), Brain (RPKM 2720.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20q11

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (28756951..28783422)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (28214229..28240501)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (29831302..29856876)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Prosaposin PS18 reduces dopaminergic neurodegeneration in a 6-hydroxydopamine rat model of Parkinson's disease.
Title: Prosaposin PS18 reduces dopaminergic neurodegeneration in a 6-hydroxydopamine rat model of Parkinson's disease.
Castration causes an increase in lysosomal size and upregulation of cathepsin D expression in principal cells along with increased secretion of procathepsin D and prosaposin oligomers in adult rat epididymis.
Title: Castration causes an increase in lysosomal size and upregulation of cathepsin D expression in principal cells along with increased secretion of procathepsin D and prosaposin oligomers in adult rat epididymis.
Prosaposin and its receptors GRP37 and GPR37L1 show increased immunoreactivity in the facial nucleus following facial nerve transection.
Title: Prosaposin and its receptors GRP37 and GPR37L1 show increased immunoreactivity in the facial nucleus following facial nerve transection.
Age- and sex-associated changes in prosaposin and its receptors in the lacrimal glands of rats.
Title: Age- and sex-associated changes in prosaposin and its receptors in the lacrimal glands of rats.
The present findings indicate that PSAP and its receptors, GPR37 and GPR37L1, are expressed in the major salivary glands of rats and their immunoreactivities differ considerably with age and sex.
Title: Prosaposin and its receptors are differentially expressed in the salivary glands of male and female rats.
Prosaposin is overexpressed following kainic acid-induced neurotoxicity
Title: Prosaposin overexpression following kainic acid-induced neurotoxicity.
Prosaposin secreted from mature neurons stimulates proliferation and maturation of immature neurons in the dentate gyrus.
Title: Temporal changes in prosaposin expression in the rat dentate gyrus after birth.
the alternatively spliced forms of mRNAs do not simply correspond to the precursor and intact forms of prosaposin.
Title: Differential expression of the alternatively spliced forms of prosaposin mRNAs in rat choroid plexus.
These findings suggest diverse functions for PSAP in the immune system.
Title: Distribution of prosaposin in rat lymphatic tissues.
Abundant expression in the perinatal stages indicates the potential role of prosaposin in the early development of the rat brain.
Title: Chronological changes in prosaposin in the developing rat brain.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH128021 (e-PCR)
- UniSTS:211330

RH138734 (e-PCR)
- UniSTS:220821

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor binding	ISO Inferred from Sequence Orthology more info
enables ganglioside GM1 binding	IEA Inferred from Electronic Annotation more info
enables ganglioside GM1 binding	ISO Inferred from Sequence Orthology more info
enables ganglioside GM2 binding	IEA Inferred from Electronic Annotation more info
enables ganglioside GM2 binding	ISO Inferred from Sequence Orthology more info
enables ganglioside GM3 binding	IEA Inferred from Electronic Annotation more info
enables ganglioside GM3 binding	ISO Inferred from Sequence Orthology more info
enables ganglioside GP1c binding	IEA Inferred from Electronic Annotation more info
enables ganglioside GP1c binding	ISO Inferred from Sequence Orthology more info
enables ganglioside GT1b binding	IEA Inferred from Electronic Annotation more info
enables ganglioside GT1b binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables lipid antigen binding	ISO Inferred from Sequence Orthology more info
enables phospholipid binding	IEA Inferred from Electronic Annotation more info
enables phospholipid binding	ISO Inferred from Sequence Orthology more info
enables protease binding	IEA Inferred from Electronic Annotation more info
enables protease binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables scaffold protein binding	IEA Inferred from Electronic Annotation more info
enables scaffold protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within NK T cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within antigen processing and presentation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to reactive oxygen species	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ceramide metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cerebellar Purkinje cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cochlea development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within corneocyte development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cornified envelope assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within developmental growth	ISO Inferred from Sequence Orthology more info
involved_in epithelial cell differentiation involved in prostate gland development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within epithelial cell differentiation involved in prostate gland development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within galactosylceramide catabolic process	ISO Inferred from Sequence Orthology more info
involved_in ganglioside GM1 transport to membrane	IEA Inferred from Electronic Annotation more info
involved_in ganglioside GM1 transport to membrane	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within_negative_effect gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glucosylceramide metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glycolipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in glycolipid transport	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within inclusion body assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intracellular protein transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lysosomal protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in lysosomal transport	IEA Inferred from Electronic Annotation more info
involved_in lysosomal transport	ISO Inferred from Sequence Orthology more info
involved_in lysosomal transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within membrane lipid metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within micturition	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within myelination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nervous system process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuromuscular process controlling balance	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of beta-galactosidase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of hydrolase activity	ISO Inferred from Sequence Orthology more info
involved_in prostate gland growth	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within prostate gland growth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in regulation of lipid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of lipid metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sensory perception of sound	ISO Inferred from Sequence Orthology more info
involved_in sphingolipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sphingolipid metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within walking behavior	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in aggresome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISS Inferred from Sequence or Structural Similarity more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in late endosome	IEA Inferred from Electronic Annotation more info
located_in late endosome	ISO Inferred from Sequence Orthology more info
located_in late endosome	ISS Inferred from Sequence or Structural Similarity more info
is_active_in lysosome	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in lysosome	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: prosaposin

Names: prosaposin (sulfated glycoprotein, sphingolipid hydrolase activator); sulfated glycoprotein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001190236.1 → NP_001177165.1 prosaposin isoform B preproprotein

See identical proteins and their annotated locations for NP_001177165.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) represents the longest transcript and encodes the longest isoform (B).

Source sequence(s)

BC061759, CK365248, CO403947, CO558861, DY313840, M19936

UniProtKB/Swiss-Prot

P10960, Q62841, Q64190

UniProtKB/TrEMBL

A6K3W9

Related

ENSRNOP00000000696.6, ENSRNOT00000000696.7

Conserved Domains (4) summary

smart00162
Location:524 → 557

SAPA; Saposin/surfactant protein-B A-type DOMAIN

smart00741
Location:441 → 515

SapB; Saposin (B) Domains

pfam03489
Location:484 → 515

SapB_2; Saposin-like type B, region 2

pfam05184
Location:63 → 97

SapB_1; Saposin-like type B, region 1
NM_001190237.1 → NP_001177166.1 prosaposin isoform C preproprotein

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate in-frame splice site in the coding region, compared to variant 2, resulting in a shorter protein (isoform C), compared to isoform B.

Source sequence(s)

BC061759, CB717025, CK365248, CO558861, DY313840

UniProtKB/Swiss-Prot

P10960, Q62841, Q64190

UniProtKB/TrEMBL

A0A8I6ASQ4

Conserved Domains (4) summary

smart00162
Location:523 → 556

SAPA; Saposin/surfactant protein-B A-type DOMAIN

smart00741
Location:440 → 514

SapB; Saposin (B) Domains

pfam03489
Location:483 → 514

SapB_2; Saposin-like type B, region 2

pfam05184
Location:63 → 97

SapB_1; Saposin-like type B, region 1
NM_001190238.1 → NP_001177167.1 prosaposin isoform D preproprotein

See identical proteins and their annotated locations for NP_001177167.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks an exon in the coding region and uses an alternate in-frame splice site, compared to variant 2, resulting in a shorter protein (isoform D), compared to isoform B.

Source sequence(s)

BC061759, CK365248, CO558861, DY313840

UniProtKB/Swiss-Prot

P10960, Q62841, Q64190

UniProtKB/TrEMBL

F7EPE0, Q6P7A4

Related

ENSRNOP00000111640.1, ENSRNOT00000128039.1

Conserved Domains (4) summary

smart00162
Location:520 → 553

SAPA; Saposin/surfactant protein-B A-type DOMAIN

smart00741
Location:437 → 511

SapB; Saposin (B) Domains

pfam03489
Location:480 → 511

SapB_2; Saposin-like type B, region 2

pfam05184
Location:63 → 97

SapB_1; Saposin-like type B, region 1
NM_013013.2 → NP_037145.2 prosaposin isoform A preproprotein

See identical proteins and their annotated locations for NP_037145.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) lacks an exon in the coding region, compared to variant 2, resulting in a shorter protein (isoform A), compared to isoform B.

Source sequence(s)

BC061759, CK365248, CO558861, DY313840, M19936

UniProtKB/Swiss-Prot

P10960, Q62841, Q64190

UniProtKB/TrEMBL

A6K3X0

Related

ENSRNOP00000096557.2, ENSRNOT00000104593.2

Conserved Domains (4) summary

smart00162
Location:521 → 554

SAPA; Saposin/surfactant protein-B A-type DOMAIN

smart00741
Location:438 → 512

SapB; Saposin (B) Domains

pfam03489
Location:481 → 512

SapB_2; Saposin-like type B, region 2

pfam05184
Location:63 → 97

SapB_1; Saposin-like type B, region 1