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    Ros1 ROS proto-oncogene 1 , receptor tyrosine kinase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25346, updated on 4-Jan-2025

    Summary

    Symbol
    Ros1provided by RGD
    Full Name
    ROS proto-oncogene 1 , receptor tyrosine kinaseprovided by RGD
    Primary source
    RGD:3591
    See related
    EnsemblRapid:ENSRNOG00000000406 AllianceGenome:RGD:3591
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    ROS1C
    Summary
    Predicted to enable protein phosphatase binding activity and transmembrane receptor protein tyrosine kinase activity. Predicted to be involved in several processes, including columnar/cuboidal epithelial cell development; protein phosphorylation; and regulation of intracellular signal transduction. Predicted to act upstream of or within several processes, including negative regulation of gene expression; peptidyl-tyrosine autophosphorylation; and regulation of phosphate transport. Predicted to be located in cell surface and perinuclear region of cytoplasm. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Orthologous to human ROS1 (ROS proto-oncogene 1, receptor tyrosine kinase). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Heart (RPKM 105.7), Kidney (RPKM 82.0) and 3 other tissues See more
    Orthologs
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    Genomic context

    See Ros1 in Genome Data Viewer
    Location:
    20q11
    Exon count:
    44
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (31975328..32126675, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (31432636..31583998, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (33100190..33323544, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene heat shock protein family D (Hsp60) member 1, pseudogene 6 Neighboring gene uncharacterized LOC134483925 Neighboring gene vestigial-like family member 2 Neighboring gene transforming growth factor beta regulator 1-like Neighboring gene discoidin, CUB and LCCL domain containing 1 Neighboring gene golgi associated PDZ and coiled-coil motif containing

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding  
    enables GPI-linked ephrin receptor activity  
    enables boss receptor activity  
    enables brain-derived neurotrophic factor receptor activity  
    enables epidermal growth factor receptor activity  
    enables fibroblast growth factor receptor activity  
    enables hepatocyte growth factor receptor activity  
    enables histone H2AXY142 kinase activity  
    enables histone H3Y41 kinase activity  
    enables insulin receptor activity  
    enables insulin-like growth factor receptor activity  
    enables macrophage colony-stimulating factor receptor activity  
    enables placental growth factor receptor activity  
    enables platelet-derived growth factor alpha-receptor activity  
    enables platelet-derived growth factor beta-receptor activity  
    enables protein phosphatase binding  
    enables protein phosphatase binding  
    enables protein tyrosine kinase activity  
    enables protein tyrosine kinase activity  
    enables protein tyrosine kinase activity  
    enables protein tyrosine kinase collagen receptor activity  
    enables stem cell factor receptor activity  
    enables transmembrane receptor protein tyrosine kinase activity  
    enables transmembrane-ephrin receptor activity  
    enables vascular endothelial growth factor receptor activity  
    Items 1 - 25 of 46
    Process Evidence Code Pubs
    involved_in Kit signaling pathway  
    involved_in brain-derived neurotrophic factor receptor signaling pathway  
    involved_in cell differentiation  
    involved_in cell differentiation  
    involved_in cell surface receptor protein tyrosine kinase signaling pathway  
    involved_in chromatin remodeling  
    involved_in collagen-activated tyrosine kinase receptor signaling pathway  
    involved_in columnar/cuboidal epithelial cell development  
    involved_in columnar/cuboidal epithelial cell development  
    involved_in columnar/cuboidal epithelial cell development  
    involved_in ephrin receptor signaling pathway  
    involved_in epidermal growth factor receptor signaling pathway  
    involved_in fibroblast growth factor receptor signaling pathway  
    involved_in gene expression  
    acts_upstream_of_or_within gene expression  
    involved_in hepatocyte growth factor receptor signaling pathway  
    involved_in insulin receptor signaling pathway  
    involved_in insulin-like growth factor receptor signaling pathway  
    involved_in macrophage colony-stimulating factor signaling pathway  
    involved_in multicellular organism development  
    involved_in negative regulation of gene expression  
    acts_upstream_of_or_within negative regulation of gene expression  
    acts_upstream_of_or_within peptidyl-tyrosine autophosphorylation  
    involved_in peptidyl-tyrosine autophosphorylation  
    involved_in platelet-derived growth factor receptor-alpha signaling pathway  
    involved_in platelet-derived growth factor receptor-beta signaling pathway  
    involved_in protein phosphorylation  
    involved_in protein phosphorylation  
    involved_in regulation of ERK1 and ERK2 cascade  
    involved_in regulation of ERK1 and ERK2 cascade  
    involved_in regulation of ERK1 and ERK2 cascade  
    involved_in regulation of TOR signaling  
    involved_in regulation of TOR signaling  
    involved_in regulation of TOR signaling  
    involved_in regulation of cell growth  
    involved_in regulation of cell growth  
    involved_in regulation of phosphate transport  
    acts_upstream_of_or_within regulation of phosphate transport  
    involved_in signal transduction  
    acts_upstream_of_or_within signal transduction  
    involved_in spermatogenesis  
    acts_upstream_of_or_within spermatogenesis  
    involved_in spermatogenesis  
    involved_in spermatogenesis  
    involved_in vascular endothelial growth factor receptor-1 signaling pathway  
    involved_in vascular endothelial growth factor signaling pathway  
    Items 1 - 25 of 46
    Component Evidence Code Pubs
    located_in cell surface  
    located_in cell surface  
    located_in perinuclear region of cytoplasm  
    located_in perinuclear region of cytoplasm  
    is_active_in plasma membrane  
    located_in plasma membrane  
    part_of receptor complex  

    General protein information

    Preferred Names
    proto-oncogene tyrosine-protein kinase ROS
    Names
    Ros1 proto-oncogene
    c-Ros receptor tyrosine kinase
    c-ros oncogene 1 , receptor tyrosine kinase
    c-ros-1
    heart - derived c - ros - 1 proto - oncogene
    proto-oncogene c-Ros
    proto-oncogene c-Ros-1
    proto-oncogene tyrosine-protein kinase ROS-like
    receptor tyrosine kinase c-ros oncogene 1
    v-ros UR2 sarcoma virus oncogene homolog 1
    NP_037006.1
    XP_008771084.1
    XP_038954373.1
    XP_038954375.1
    XP_063135044.1
    XP_063135045.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012874.1NP_037006.1  proto-oncogene tyrosine-protein kinase ROS precursor

      See identical proteins and their annotated locations for NP_037006.1

      Status: PROVISIONAL

      Source sequence(s)
      M35106
      UniProtKB/Swiss-Prot
      Q63130, Q63131, Q63132
      UniProtKB/TrEMBL
      A0A8L2UH45, A6K478
      Related
      ENSRNOP00000000459.6, ENSRNOT00000000459.7
      Conserved Domains (4) summary
      smart00219
      Location:19472207
      TyrKc; Tyrosine kinase, catalytic domain
      smart00060
      Location:14481526
      FN3; Fibronectin type 3 domain
      cd00063
      Location:211290
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05044
      Location:19472208
      PTKc_c-ros; Catalytic domain of the Protein Tyrosine Kinase, C-ros

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      31975328..32126675 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008772862.4XP_008771084.1  proto-oncogene tyrosine-protein kinase ROS isoform X3

      See identical proteins and their annotated locations for XP_008771084.1

      UniProtKB/TrEMBL
      A0A8L2UH45, A6K476
      Conserved Domains (4) summary
      smart00219
      Location:19262186
      TyrKc; Tyrosine kinase, catalytic domain
      smart00060
      Location:14271505
      FN3; Fibronectin type 3 domain
      cd00063
      Location:211290
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05044
      Location:19262187
      PTKc_c-ros; Catalytic domain of the Protein Tyrosine Kinase, C-ros
    2. XM_039098447.2XP_038954375.1  proto-oncogene tyrosine-protein kinase ROS isoform X2

      UniProtKB/TrEMBL
      A0A8L2UH45
      Conserved Domains (3) summary
      smart00060
      Location:111178
      FN3; Fibronectin type 3 domain
      cd00063
      Location:211290
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05044
      Location:19272188
      PTKc_c-ros; Catalytic domain of the Protein Tyrosine Kinase, C-ros
    3. XM_039098445.2XP_038954373.1  proto-oncogene tyrosine-protein kinase ROS isoform X1

      UniProtKB/TrEMBL
      A0A8L2UH45, A0A8L2UPK7
      Related
      ENSRNOP00000068996.2, ENSRNOT00000080444.3
      Conserved Domains (3) summary
      smart00060
      Location:111178
      FN3; Fibronectin type 3 domain
      cd00063
      Location:211290
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05044
      Location:19482209
      PTKc_c-ros; Catalytic domain of the Protein Tyrosine Kinase, C-ros
    4. XM_063278975.1XP_063135045.1  proto-oncogene tyrosine-protein kinase ROS isoform X5

    5. XM_063278974.1XP_063135044.1  proto-oncogene tyrosine-protein kinase ROS isoform X4

      UniProtKB/TrEMBL
      A0A8L2UH45
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