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    Hspa12b heat shock protein family A (Hsp70) member 12B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311427, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hspa12bprovided by RGD
    Official Full Name
    heat shock protein family A (Hsp70) member 12Bprovided by RGD
    Primary source
    RGD:1312004
    See related
    EnsemblRapid:ENSRNOG00000021244 AllianceGenome:RGD:1312004
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Orthologous to human HSPA12B (heat shock protein family A (Hsp70) member 12B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 182.5), Heart (RPKM 136.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Hspa12b in Genome Data Viewer
    Location:
    3q36
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (138799396..138817396)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (118346372..118364374)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (123670219..123688640)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene ribosomal protein L12, pseudogene 12 Neighboring gene adipose secreted signaling protein Neighboring gene sperm flagellar 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Expression of HSPA12B in acute cardiac allograft rejection in rats. Shi J, et al. Pathol Res Pract, 2015 Jan. PMID 25433995
    2. The role of HSPA12B in regulating neuronal apoptosis. Kang L, et al. Neurochem Res, 2013 Feb. PMID 23292195
    3. Lipopolysaccharide-evoked HSPA12B expression by activation of MAPK cascade in microglial cells of the spinal cord. Cui Z, et al. J Neurol Sci, 2010 Jul 15. PMID 20488464
    4. Regulation of A-Kinase-Anchoring Protein 12 by Heat Shock Protein A12B to Prevent Ventricular Dysfunction Following Acute Myocardial Infarction in Diabetic Rats. Selvaraju V, et al. J Cardiovasc Transl Res, 2017 Apr. PMID 28281242
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HSPA12B overexpression interacts with AKAP12 and downregulate TXNIP in diabetic rats following acute myocardial infarction.
      Title: Regulation of A-Kinase-Anchoring Protein 12 by Heat Shock Protein A12B to Prevent Ventricular Dysfunction Following Acute Myocardial Infarction in Diabetic Rats.
    2. HSPA12B might play crucial roles in heart pathophysiology after transplantation
      Title: Expression of HSPA12B in acute cardiac allograft rejection in rats.
    3. The expression of HSPA12B may be required for protecting neurons from ischemic insults.
      Title: The role of HSPA12B in regulating neuronal apoptosis.
    4. results suggested HSPA12B may be important for host defense in microglia-mediated immune response; understanding the cell signal pathway may provide a novel strategy against inflammatory and immune reaction in neuroinflammtion in CNS
      Title: Lipopolysaccharide-evoked HSPA12B expression by activation of MAPK cascade in microglial cells of the spinal cord.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    General protein information

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    Preferred Names
    heat shock 70 kDa protein 12B
    Names
    heat shock protein 12B
    heat shock protein 70kDa 12B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395016.1 → NP_001381945.1  heat shock 70 kDa protein 12B

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I5Y935, D3ZVM5
      Related
      ENSRNOP00000028856.6, ENSRNOT00000028856.9
      Conserved Domains (1) summary
      cl17037
      Location:61 → 529
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    2. NM_001395017.1 → NP_001381946.1  heat shock 70 kDa protein 12B

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I5Y935, D3ZVM5
      Conserved Domains (1) summary
      cl17037
      Location:61 → 529
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      138799396..138817396
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001107778.1: Suppressed sequence

      Description
      NM_001107778.1: This RefSeq was removed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version

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