Champ1 chromosome alignment maintaining phosphoprotein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Champ1provided by RGD
Official Full Name: chromosome alignment maintaining phosphoprotein 1provided by RGD
Primary source: RGD:1311283
See related: EnsemblRapid:ENSRNOG00000000112 AllianceGenome:RGD:1311283
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Zfp828; RGD1311283
Summary: Predicted to be involved in attachment of spindle microtubules to kinetochore and protein localization to organelle. Predicted to be located in kinetochore; nuclear body; and spindle. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 40. Orthologous to human CHAMP1 (chromosome alignment maintaining phosphoprotein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 64.8), Kidney (RPKM 64.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16q12.5

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (82436172..82447144, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (75733958..75744931, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (80839373..80850340, complement)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Serum levels of pNF-H immunoreactivity may be used to conveniently monitor neuronal damage and degeneration in experimental and presumably clinical situations.
Title: Hyperphosphorylated neurofilament NF-H is a serum biomarker of axonal injury.
Electrophysiological consequences of cerebellar white matter injury and temporal profile of NF200 and spectrin degradation following forebrain fluid percussion injury.
Title: Heavy neurofilament accumulation and alpha-spectrin degradation accompany cerebellar white matter functional deficits following forebrain fluid percussion injury.

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General gene information

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Markers

AU049290 (e-PCR)
- UniSTS:145738

RH129359 (e-PCR)
- UniSTS:212666

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in attachment of mitotic spindle microtubules to kinetochore	ISO Inferred from Sequence Orthology more info
involved_in protein localization to kinetochore	ISO Inferred from Sequence Orthology more info
involved_in protein localization to microtubule	ISO Inferred from Sequence Orthology more info
involved_in sister chromatid biorientation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in condensed chromosome	ISO Inferred from Sequence Orthology more info
located_in kinetochore	ISO Inferred from Sequence Orthology more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in spindle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: chromosome alignment-maintaining phosphoprotein 1

Names: zinc finger protein 828

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.