Srm spermidine synthase [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Srmprovided by RGD
Full Name: spermidine synthaseprovided by RGD
Primary source: RGD:620796
See related: EnsemblRapid:ENSRNOG00000011258 AllianceGenome:RGD:620796
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables spermidine synthase activity. Involved in spermidine biosynthetic process. Predicted to be active in cytosol. Orthologous to human SRM (spermidine synthase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 98.4), Muscle (RPKM 94.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (164309002..164312203)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (159025875..159029076)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (165405168..165408325)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Spermidine Synthase Localization in Retinal Layers: Early Age Changes.
Title: Spermidine Synthase Localization in Retinal Layers: Early Age Changes.
The neuropil labelling in the patch compartment and in adjacent putative interneurones may indicate a role for polyamines in intercompartmental signalling in the striatum.
Title: Spermidine synthase is prominently expressed in the striatal patch compartment and in putative interneurones of the matrix compartment.

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General gene information

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Markers

Srm (e-PCR), detects polymorphism
- UniSTS:531490

AA858619 (e-PCR)
- UniSTS:261172

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables spermidine synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables spermidine synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables spermidine synthase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables spermidine synthase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to leukemia inhibitory factor	ISO Inferred from Sequence Orthology more info
involved_in spermidine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in spermidine biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in spermidine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermidine biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: spermidine synthase

NP_445916.1

EC 2.5.1.16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.