Ndor1 NADPH dependent diflavin oxidoreductase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ndor1provided by MGI
Official Full Name: NADPH dependent diflavin oxidoreductase 1provided by MGI
Primary source: MGI:MGI:1926047
See related: Ensembl:ENSMUSG00000006471 Ensembl:ENSMUSG00000115074 AllianceGenome:MGI:1926047
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NR1; Ndor; Ubc-cre; 4930447P04Rik; Tg(UBC-cre/ERT2)1Ejb
Summary: Predicted to enable several functions, including NADPH-hemoprotein reductase activity; nucleotide binding activity; and oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor. Predicted to be involved in electron transport chain. Predicted to be located in cytoplasm; intermediate filament cytoskeleton; and nucleoplasm. Predicted to be active in cytosol. Orthologous to human NDOR1 (NADPH dependent diflavin oxidoreductase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in thymus adult (RPKM 16.6), spleen adult (RPKM 13.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 A3; 2 17.1 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (25134825..25145458, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (25244813..25255509, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Transgenic (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables FAD binding	IEA Inferred from Electronic Annotation more info
enables FAD binding	ISO Inferred from Sequence Orthology more info
enables FMN binding	IBA Inferred from Biological aspect of Ancestor more info
enables FMN binding	IEA Inferred from Electronic Annotation more info
enables FMN binding	ISO Inferred from Sequence Orthology more info
enables NADP binding	ISO Inferred from Sequence Orthology more info
enables NADPH binding	IEA Inferred from Electronic Annotation more info
enables NADPH binding	ISO Inferred from Sequence Orthology more info
enables NADPH-hemoprotein reductase activity	IEA Inferred from Electronic Annotation more info
enables NADPH-hemoprotein reductase activity	ISO Inferred from Sequence Orthology more info
enables electron transfer activity	ISO Inferred from Sequence Orthology more info
enables electron transfer activity	ISS Inferred from Sequence or Structural Similarity more info
enables flavin adenine dinucleotide binding	IBA Inferred from Biological aspect of Ancestor more info
enables oxidoreductase activity	IBA Inferred from Biological aspect of Ancestor more info
enables oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor	ISS Inferred from Sequence or Structural Similarity more info
enables oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in electron transport chain	IEA Inferred from Electronic Annotation more info
involved_in electron transport chain	ISO Inferred from Sequence Orthology more info
involved_in iron-sulfur cluster assembly	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in intermediate filament cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in intermediate filament cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: NADPH-dependent diflavin oxidoreductase 1

Names: NADPH-dependent FMN and FAD-containing oxidoreductase; Tg(UBC-cre)1Ejb; Tg(UBC-cre/ESR1)1Ejb

NP_001075945.1

EC 1.6.-.-

NP_001239470.1

EC 1.6.-.-

NP_001239471.1

EC 1.6.-.-

XP_006498504.1

EC 1.6.-.-

XP_006498505.1

EC 1.6.-.-

XP_006498506.1

EC 1.6.-.-

XP_006498507.1

EC 1.6.-.-

XP_006498508.1

EC 1.6.-.-

XP_006498509.1

EC 1.6.-.-

XP_006498510.1

EC 1.6.-.-

XP_006498511.1

EC 1.6.-.-

XP_006498513.1

EC 1.6.-.-

XP_006498514.1

EC 1.6.-.-

XP_006498515.1

EC 1.6.-.-

XP_006498518.1

EC 1.6.-.-

XP_030108111.1

EC 1.6.-.-

XP_030108112.1

EC 1.6.-.-

XP_030108113.1

EC 1.6.-.-

XP_036018619.1

EC 1.6.-.-

XP_036018620.1

EC 1.6.-.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001082476.2 → NP_001075945.1 NADPH-dependent diflavin oxidoreductase 1 isoform 1

See identical proteins and their annotated locations for NP_001075945.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.

Source sequence(s)

AK019617, AL732309

Consensus CDS

CCDS38069.1

UniProtKB/Swiss-Prot

A2AI05, Q3TQZ6, Q80WC5

Related

ENSMUSP00000109989.3, ENSMUST00000114349.9

Conserved Domains (3) summary

COG0369
Location:6 → 597

CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]

pfam00258
Location:8 → 145

Flavodoxin_1; Flavodoxin

cl06868
Location:212 → 597

FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...
NM_001252541.1 → NP_001239470.1 NADPH-dependent diflavin oxidoreductase 1 isoform 2

See identical proteins and their annotated locations for NP_001239470.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks two consecutive exons in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

AK163207, AL732309

Consensus CDS

CCDS57157.1

UniProtKB/Swiss-Prot

A2AI05

Related

ENSMUSP00000097903.4, ENSMUST00000100329.10

Conserved Domains (3) summary

COG0369
Location:6 → 530

CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]

pfam00258
Location:8 → 123

Flavodoxin_1; Flavodoxin

cl06868
Location:145 → 530

FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...
NM_001252542.1 → NP_001239471.1 NADPH-dependent diflavin oxidoreductase 1 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' and 3' UTRs and has multiple differences in the coding region, one of which results in a translational frameshift, compared to variant 1. The encoded isoform (3) is longer and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AK143124, AL732309

Consensus CDS

CCDS89442.1

UniProtKB/TrEMBL

A0A2I3BQN1

Related

ENSMUSP00000154261.2, ENSMUST00000228052.2

Conserved Domains (3) summary

COG0369
Location:1 → 450

CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]

pfam00258
Location:1 → 76

Flavodoxin_1; Flavodoxin

cl06868
Location:143 → 450

FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

25134825..25145458 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006498446.5 → XP_006498509.1 NADPH-dependent diflavin oxidoreductase 1 isoform X5

Conserved Domains (1) summary

COG0369
Location:6 → 519

CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
XM_036162726.1 → XP_036018619.1 NADPH-dependent diflavin oxidoreductase 1 isoform X11

Conserved Domains (1) summary

COG0369
Location:6 → 551

CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
XM_006498455.5 → XP_006498518.1 NADPH-dependent diflavin oxidoreductase 1 isoform X14

Conserved Domains (1) summary

COG0369
Location:98 → 570

CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
XM_006498441.5 → XP_006498504.1 NADPH-dependent diflavin oxidoreductase 1 isoform X1

Conserved Domains (1) summary

COG0369
Location:98 → 570

CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
XM_006498451.5 → XP_006498514.1 NADPH-dependent diflavin oxidoreductase 1 isoform X8

See identical proteins and their annotated locations for XP_006498514.1

Conserved Domains (1) summary

COG0369
Location:98 → 570

CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
XM_006498450.5 → XP_006498513.1 NADPH-dependent diflavin oxidoreductase 1 isoform X8

See identical proteins and their annotated locations for XP_006498513.1

Conserved Domains (1) summary

COG0369
Location:98 → 570

CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
XM_006498447.5 → XP_006498510.1 NADPH-dependent diflavin oxidoreductase 1 isoform X6

Conserved Domains (1) summary

COG0369
Location:98 → 602

CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
XM_006498445.5 → XP_006498508.1 NADPH-dependent diflavin oxidoreductase 1 isoform X4

See identical proteins and their annotated locations for XP_006498508.1

Conserved Domains (1) summary

COG0369
Location:98 → 602

CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
XM_006498444.5 → XP_006498507.1 NADPH-dependent diflavin oxidoreductase 1 isoform X4

See identical proteins and their annotated locations for XP_006498507.1

Conserved Domains (1) summary

COG0369
Location:98 → 602

CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
XM_006498452.4 → XP_006498515.1 NADPH-dependent diflavin oxidoreductase 1 isoform X10

Conserved Domains (2) summary

pfam00258
Location:1 → 76

Flavodoxin_1

cl06868
Location:143 → 450

FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...
XM_030252252.2 → XP_030108112.1 NADPH-dependent diflavin oxidoreductase 1 isoform X13

Conserved Domains (1) summary

cl06868
Location:59 → 366

FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...
XM_006498448.5 → XP_006498511.1 NADPH-dependent diflavin oxidoreductase 1 isoform X7

Conserved Domains (1) summary

COG0369
Location:25 → 497

CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
XM_030252253.2 → XP_030108113.1 NADPH-dependent diflavin oxidoreductase 1 isoform X13

Conserved Domains (1) summary

cl06868
Location:59 → 366

FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...
XM_006498442.5 → XP_006498505.1 NADPH-dependent diflavin oxidoreductase 1 isoform X2

Conserved Domains (1) summary

COG0369
Location:98 → 570

CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
XM_036162727.1 → XP_036018620.1 NADPH-dependent diflavin oxidoreductase 1 isoform X12

Conserved Domains (2) summary

pfam00258
Location:1 → 76

Flavodoxin_1

cl06868
Location:143 → 528

FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...
XM_006498443.5 → XP_006498506.1 NADPH-dependent diflavin oxidoreductase 1 isoform X3

Conserved Domains (1) summary

COG0369
Location:98 → 648

CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
XM_030252251.2 → XP_030108111.1 NADPH-dependent diflavin oxidoreductase 1 isoform X9

Conserved Domains (1) summary

COG0369
Location:25 → 575

CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]

RNA

XR_004940781.1 RNA Sequence
XR_004940780.1 RNA Sequence
XR_004940779.1 RNA Sequence
XR_004940778.1 RNA Sequence
XR_004940777.1 RNA Sequence
XR_374139.5 RNA Sequence
XR_374138.5 RNA Sequence
XR_003953749.2 RNA Sequence
XR_866029.4 RNA Sequence
XR_866028.4 RNA Sequence
XR_374141.5 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_178239.2: Suppressed sequence

Description

NM_178239.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.