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    Ddi1 DNA-damage inducible 1 [ Mus musculus (house mouse) ]

    Gene ID: 71829, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ddi1provided by MGI
    Official Full Name
    DNA-damage inducible 1provided by MGI
    Primary source
    MGI:MGI:1919079
    See related
    Ensembl:ENSMUSG00000047619 AllianceGenome:MGI:1919079
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700011N24Rik
    Summary
    Predicted to enable aspartic-type endopeptidase activity. Predicted to be involved in several processes, including cellular response to hydroxyurea; regulation of DNA stability; and regulation of protein stability. Is expressed in brain and future brain. Orthologous to human DDI1 (DNA damage inducible 1 homolog 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human all
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    Genomic context

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    See Ddi1 in Genome Data Viewer
    Location:
    9 A1; 9 2.46 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (6265028..6266547, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (6265028..6266547, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_23188 Neighboring gene heat shock protein 90 alpha (cytosolic), class B member 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_23189 Neighboring gene STARR-seq mESC enhancer starr_23190 Neighboring gene non-POU-domain-containing, octamer binding protein pseudogene Neighboring gene platelet-derived growth factor, D polypeptide Neighboring gene STARR-seq mESC enhancer starr_23191 Neighboring gene STARR-seq mESC enhancer starr_23193 Neighboring gene STARR-seq mESC enhancer starr_23194 Neighboring gene STARR-seq mESC enhancer starr_23195 Neighboring gene predicted gene, 21089 Neighboring gene predicted gene, 23097

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Normal spermatogenesis and fertility in Ddi1 (DNA damage inducible 1) mutant mice. Yousaf A, et al. Reprod Biol, 2020 Dec. PMID 33092996
    2. Quantitative proteomics reveals neuronal ubiquitination of Rngo/Ddi1 and several proteasomal subunits by Ube3a, accounting for the complexity of Angelman syndrome. Ramirez J, et al. Hum Mol Genet, 2018 Jun 1. PMID 29788202
    3. DDI2 protease controls embryonic development and inflammation via TCF11/NRF1. Nedomova M, et al. iScience, 2024 Oct 18. PMID 39328932, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Normal spermatogenesis and fertility in Ddi1 (DNA damage inducible 1) mutant mice.
      Title: Normal spermatogenesis and fertility in Ddi1 (DNA damage inducible 1) mutant mice.
    2. The novel observation that DDI1 is expressed in the developing mice brain, with a significant peak at E16.5, strongly suggests that DDI1 has biological functions not yet described that could be of relevance for Angelman syndrome clinical research.
      Title: Quantitative proteomics reveals neuronal ubiquitination of Rngo/Ddi1 and several proteasomal subunits by Ube3a, accounting for the complexity of Angelman syndrome.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables aspartic-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to hydroxyurea ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to hydroxyurea ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in proteasomal protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasomal protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of DNA stability ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA stability ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of protein stability ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein stability ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    protein DDI1 homolog 1
    Names
    DDI1, DNA-damage inducible 1, homolog 1
    NP_082218.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027942.1 → NP_082218.1  protein DDI1 homolog 1

      See identical proteins and their annotated locations for NP_082218.1

      Status: PROVISIONAL

      Source sequence(s)
      AK005882
      Consensus CDS
      CCDS40527.1
      UniProtKB/Swiss-Prot
      Q9DAF3
      Related
      ENSMUSP00000053223.5, ENSMUST00000051706.6
      Conserved Domains (2) summary
      cd05479
      Location:235 → 357
      RP_DDI; retropepsin-like domain of DNA damage inducible protein
      cd01796
      Location:1 → 76
      Ubl_Ddi1_like; ubiquitin-like (Ubl) domain found in the eukaryotic Ddi1 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      6265028..6266547 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DAF3.1 GenPept UniProtKB/Swiss-Prot:Q9DAF3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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