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    Txndc5 thioredoxin domain containing 5 [ Mus musculus (house mouse) ]

    Gene ID: 105245, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Txndc5provided by MGI
    Official Full Name
    thioredoxin domain containing 5provided by MGI
    Primary source
    MGI:MGI:2145316
    See related
    Ensembl:ENSMUSG00000038991 AllianceGenome:MGI:2145316
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ERp46; PC-TRP
    Summary
    Enables protein disulfide isomerase activity and protein-disulfide reductase activity. Predicted to be involved in protein folding. Located in endoplasmic reticulum lumen. Is expressed in several structures, including brain; eye; immune system; intestine; and male reproductive gland or organ. Orthologous to human TXNDC5 (thioredoxin domain containing 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in colon adult (RPKM 145.4), adrenal adult (RPKM 131.5) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Txndc5 in Genome Data Viewer
    Location:
    13 A3.3; 13 18.27 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (38684242..38712800, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (38500266..38528824, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 47990 Neighboring gene bone morphogenetic protein 6 Neighboring gene RIKEN cDNA 4930579J19 gene Neighboring gene STARR-seq mESC enhancer starr_34248 Neighboring gene predicted gene, 31834 Neighboring gene predicted gene, 40922 Neighboring gene biogenesis of lysosomal organelles complex-1, subunit 5, muted Neighboring gene STARR-seq mESC enhancer starr_34249

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Thioredoxin domain containing 5 is involved in the hepatic storage of squalene into lipid droplets in a sex-specific way. Sánchez-Marco J, et al. J Nutr Biochem, 2024 Feb. PMID 37898391
    2. Identification of a novel thioredoxin-related protein, PC-TRP, which is preferentially expressed in plasma cells. Wrammert J, et al. Eur J Immunol, 2004 Jan. PMID 14971039
    3. ERp46 is reduced by high glucose and regulates insulin content in pancreatic beta-cells. Alberti A, et al. Am J Physiol Endocrinol Metab, 2009 Sep. PMID 19622788
    4. Involvement of thioredoxin domain-containing 5 in resistance to nitrosative stress. Lee HW, et al. Free Radic Biol Med, 2010 Sep 1. PMID 20550962
    5. Proteomics and gene expression analyses of squalene-supplemented mice identify microsomal thioredoxin domain-containing protein 5 changes associated with hepatic steatosis. Ramírez-Torres A, et al. J Proteomics, 2012 Dec 21. PMID 22796066

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Thioredoxin domain containing 5 is involved in the hepatic storage of squalene into lipid droplets in a sex-specific way.
      Title: Thioredoxin domain containing 5 is involved in the hepatic storage of squalene into lipid droplets in a sex-specific way.
    2. A novel role for endoplasmic reticulum protein 46 (ERp46) in platelet function and arterial thrombosis in mice.
      Title: A novel role for endoplasmic reticulum protein 46 (ERp46) in platelet function and arterial thrombosis in mice.
    3. Endoplasmic reticulum protein TXNDC5 promotes renal fibrosis by enforcing TGF-beta signaling in kidney fibroblasts.
      Title: Endoplasmic reticulum protein TXNDC5 promotes renal fibrosis by enforcing TGF-β signaling in kidney fibroblasts.
    4. Inhibition of ER stress by targeting the IRE1alpha-TXNDC5 pathway alleviates crystalline silica-induced pulmonary fibrosis.
      Title: Inhibition of ER stress by targeting the IRE1α-TXNDC5 pathway alleviates crystalline silica-induced pulmonary fibrosis.
    5. Fibroblast-enriched endoplasmic reticulum protein TXNDC5 promotes pulmonary fibrosis by augmenting TGFbeta signaling through TGFBR1 stabilization.
      Title: Fibroblast-enriched endoplasmic reticulum protein TXNDC5 promotes pulmonary fibrosis by augmenting TGFβ signaling through TGFBR1 stabilization.
    6. TXNDC5 mRNA and protein were highly upregulated in hypertrophied/failing mouse left ventricle. Targeted disruption of Txndc5 in mice revealed protective effects against isoproterenol-induced cardiac hypertrophy, reduced fibrosis by approximately 70%, and markedly improved left ventricle function.
      Title: Endoplasmic Reticulum Protein TXNDC5 Augments Myocardial Fibrosis by Facilitating Extracellular Matrix Protein Folding and Redox-Sensitive Cardiac Fibroblast Activation.
    7. Hypoxia induced TXCNDC5 expression, which contributed to adiponectin expression, cytokine production and the cellular proliferation and migration of fibroblasts in rheumatoid arthritis.
      Title: Investigate pathogenic mechanism of TXNDC5 in rheumatoid arthritis.
    8. Txndc5 reflects the anti-steatotic properties of squalene and the sensitivity to lipid accumulation.
      Title: Proteomics and gene expression analyses of squalene-supplemented mice identify microsomal thioredoxin domain-containing protein 5 changes associated with hepatic steatosis.
    9. ERp46 plays a protective role in palmitic acid -induced cell apoptosis by decreasing the endoplasmic reticulum stress response and might be a novel target for anti-diabetic drugs.
      Title: Role of ERp46 in β-cell lipoapoptosis through endoplasmic reticulum stress pathway as well as the protective effect of exendin-4.
    10. Potential role for TXNDC5 in resistance to nitrosative stress.
      Title: Involvement of thioredoxin domain-containing 5 in resistance to nitrosative stress.
    Submit: New GeneRIF Correction See all GeneRIFs (13)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein disulfide isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein disulfide isomerase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables protein-disulfide reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum lumen IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    thioredoxin domain-containing protein 5
    Names
    ER protein 46
    endoplasmic reticulum protein ERp46
    endoplasmic reticulum resident protein 46
    plasma cell-specific thioredoxin-related protein
    thioredoxin-like protein p46
    NP_001276527.1
    NP_001276528.1
    NP_663342.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289598.1 → NP_001276527.1  thioredoxin domain-containing protein 5 isoform 2

      See identical proteins and their annotated locations for NP_001276527.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains a distinct 5' UTR and represents translation initiation at an in-frame downstream AUG, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC154747, AK136046, AK224956, AY243534
      Consensus CDS
      CCDS79178.1
      UniProtKB/TrEMBL
      A0A0R4J1Y7, Q3UWX1
      Related
      ENSMUSP00000124516.2, ENSMUST00000162075.8
      Conserved Domains (3) summary
      cd03005
      Location:82 → 182
      PDI_a_ERp46; PDIa family, endoplasmic reticulum protein 46 (ERp46) subfamily; ERp46 is an ER-resident protein containing three redox active TRX domains. Yeast complementation studies show that ERp46 can substitute for protein disulfide isomerase (PDI) function in ...
      TIGR01130
      Location:85 → 323
      ER_PDI_fam; protein disulfide isomerase, eukaryotic
      cl00388
      Location:2 → 56
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

    2. NM_001289599.1 → NP_001276528.1  thioredoxin domain-containing protein 5 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains a distinct 5' UTR and coding region and represents translation initiation at a novel AUG, compared to variant 1. The resulting isoform (3) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK225017, AY243534
      Consensus CDS
      CCDS79179.1
      UniProtKB/TrEMBL
      E9PXX7, Q3UBW8
      Related
      ENSMUSP00000124401.2, ENSMUST00000160653.2
      Conserved Domains (3) summary
      cd03005
      Location:103 → 203
      PDI_a_ERp46; PDIa family, endoplasmic reticulum protein 46 (ERp46) subfamily; ERp46 is an ER-resident protein containing three redox active TRX domains. Yeast complementation studies show that ERp46 can substitute for protein disulfide isomerase (PDI) function in ...
      TIGR01130
      Location:2 → 344
      ER_PDI_fam; protein disulfide isomerase, eukaryotic
      cl00388
      Location:2 → 77
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

    3. NM_145367.4 → NP_663342.3  thioredoxin domain-containing protein 5 isoform 1 precursor

      See identical proteins and their annotated locations for NP_663342.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK224971, AK225023, AY243534
      Consensus CDS
      CCDS26463.1
      UniProtKB/Swiss-Prot
      Q8R1I6, Q91W90
      UniProtKB/TrEMBL
      Q3TEE8, Q3UBW8
      Related
      ENSMUSP00000041839.9, ENSMUST00000035988.16
      Conserved Domains (2) summary
      cd03005
      Location:176 → 276
      PDI_a_ERp46; PDIa family, endoplasmic reticulum protein 46 (ERp46) subfamily; ERp46 is an ER-resident protein containing three redox active TRX domains. Yeast complementation studies show that ERp46 can substitute for protein disulfide isomerase (PDI) function in ...
      TIGR01130
      Location:52 → 417
      ER_PDI_fam; protein disulfide isomerase, eukaryotic

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      38684242..38712800 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91W90.2 GenPept UniProtKB/Swiss-Prot:Q91W90

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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