Bcl6b B cell CLL/lymphoma 6, member B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Bcl6bprovided by MGI
Official Full Name: B cell CLL/lymphoma 6, member Bprovided by MGI
Primary source: MGI:MGI:1278332
See related: Ensembl:ENSMUSG00000000317 AllianceGenome:MGI:1278332
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Bazf
Summary: Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in genitourinary system; heart; and lung. Orthologous to human BCL6B (BCL6B transcription repressor). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in lung adult (RPKM 7.9), subcutaneous fat pad adult (RPKM 6.5) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B3; 11 42.99 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (70114953..70120624, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (70224127..70229798, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

BCL6B Contributes to Ocular Vascular Diseases via Notch Signal Silencing.
Title: BCL6B Contributes to Ocular Vascular Diseases via Notch Signal Silencing.
Epigenetic inactivation of Bcl6b promotes gastric cancer through amplification of the gastric inflammatory response in vivo
Title: Inhibition of Bcl6b promotes gastric cancer by amplifying inflammation in mice.
Mouse germline stem (GS) cell transfected with an activated form of Map2k1 have upregulated Etv5 and Bcl6b gene expression.
Title: FGF2 mediates mouse spermatogonial stem cell self-renewal via upregulation of Etv5 and Bcl6b through MAP2K1 activation.
GDNF up-regulation of Bcl6b, Erm, and Lhx1 expression through Src family kinase signaling is a key component of the intracellular mechanism for spermatogonial stem cells self-renewal.
Title: Glial cell line-derived neurotrophic factor regulation of genes essential for self-renewal of mouse spermatogonial stem cells is dependent on Src family kinase signaling.
represses Bcl6-dependent transcription.
Title: Bcl6-dependent transcriptional repression by BAZF.
BCL6b is required for the enhanced magnitude of the secondary response of memory CD8(+) T cells.
Title: BCL6b mediates the enhanced magnitude of the secondary response of memory CD8+ T lymphocytes.
Both BCL-6 and BAZF regulate hematopoietic progenitor cells homeostasis by an indirect pathway involving CD8 T cells.
Title: Aberrant regulation of hematopoiesis by T cells in BAZF-deficient mice.
DNA-binding protein; gene expression regulation; binds STAT6 elements; binding site specificity
Title: Binding of BAZF and Bc16 to STAT6-binding DNA sequences.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cytokine production	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of immune system process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in type 2 immune response	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: B-cell CLL/lymphoma 6 member B protein

Names: BcL6-associated zinc finger protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007528.3 → NP_031554.1 B-cell CLL/lymphoma 6 member B protein

See identical proteins and their annotated locations for NP_031554.1

Status: VALIDATED

Source sequence(s)

AL669869, BC090998, BY730334

Consensus CDS

CCDS24939.1

UniProtKB/Swiss-Prot

O88282, Q8CCJ6

UniProtKB/TrEMBL

Q5BKP3

Related

ENSMUSP00000000326.6, ENSMUST00000000326.12

Conserved Domains (4) summary

smart00225
Location:39 → 131

BTB; Broad-Complex, Tramtrack and Bric a brac

sd00017
Location:325 → 345

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00651
Location:28 → 132

BTB; BTB/POZ domain

pfam13465
Location:365 → 390

zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

70114953..70120624 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030245494.1 → XP_030101354.1 B-cell CLL/lymphoma 6 member B protein isoform X1

Conserved Domains (3) summary

COG5189
Location:199 → 306

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

sd00017
Location:206 → 226

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:303 → 327

zf-H2C2_2; Zinc-finger double domain