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    MAGOHB mago homolog B, exon junction complex subunit [ Homo sapiens (human) ]

    Gene ID: 55110, updated on 4-Jan-2025

    Summary

    Official Symbol
    MAGOHBprovided by HGNC
    Official Full Name
    mago homolog B, exon junction complex subunitprovided by HGNC
    Primary source
    HGNC:HGNC:25504
    See related
    Ensembl:ENSG00000111196 MIM:619552; AllianceGenome:HGNC:25504
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MGN2; mago; magoh
    Summary
    Enables RNA binding activity. Involved in mRNA splicing, via spliceosome and nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. Located in nucleus. Part of U2-type catalytic step 1 spliceosome; U2-type precatalytic spliceosome; and exon-exon junction subcomplex mago-y14. [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in endometrium (RPKM 3.2), appendix (RPKM 3.0) and 25 other tissues See more
    Orthologs
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    Genomic context

    See MAGOHB in Genome Data Viewer
    Location:
    12p13.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (10599524..10613609, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (10472850..10486915, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (10756789..10766208, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene SLC25A39 pseudogene 2 Neighboring gene long intergenic non-protein coding RNA 2446 Neighboring gene uncharacterized LOC105376675 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:10724334-10724939 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr12:10733376-10734575 Neighboring gene killer cell lectin like receptor A1, pseudogene Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr12:10765265-10766144 and GRCh37_chr12:10766145-10767022 Neighboring gene serine/threonine/tyrosine kinase 1 Neighboring gene Y-box binding protein 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4238 Neighboring gene uncharacterized LOC124902876 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4239 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4240

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Expression of HIV-1 Tat downregulates the abundance of mago-nashi homolog B (MAGOHB) in the nucleoli of Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    General gene information

    Clone Names

    • FLJ10292

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    part_of U2-type catalytic step 1 spliceosome PubMed 
    part_of U2-type precatalytic spliceosome PubMed 
    part_of catalytic step 2 spliceosome  
    located_in cytosol PubMed 
    part_of exon-exon junction complex  
    part_of exon-exon junction complex PubMed 
    part_of exon-exon junction complex  
    part_of exon-exon junction subcomplex mago-y14 PubMed 
    located_in neuronal cell body  
    located_in nucleoplasm  
    located_in nucleus PubMed 
    located_in nucleus PubMed 

    General protein information

    Preferred Names
    protein mago nashi homolog 2
    Names
    mago homolog B, exon junction complex core component
    mago-nashi homolog B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001300739.2 → NP_001287668.1  protein mago nashi homolog 2 isoform 2

      See identical proteins and their annotated locations for NP_001287668.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' structure and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2 and 3 encode the same isoform (2).
      Source sequence(s)
      AC021049, BG497574, BU933036, DB340467
      Consensus CDS
      CCDS76532.1
      UniProtKB/TrEMBL
      F5H6P7
      Conserved Domains (1) summary
      cl03715
      Location:1 → 102
      Mago_nashi; Mago nashi proteins, integral members of the exon junction complex
    2. NM_001319985.2 → NP_001306914.1  protein mago nashi homolog 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 5' region and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2 and 3 encode the same isoform (2).
      Source sequence(s)
      AC021049, AF165518, BF667243, BG533740, CD357202
      Consensus CDS
      CCDS76532.1
      UniProtKB/TrEMBL
      F5H6P7
      Related
      ENSP00000437462.1, ENST00000539554.6
      Conserved Domains (1) summary
      cl03715
      Location:1 → 102
      Mago_nashi; Mago nashi proteins, integral members of the exon junction complex
    3. NM_018048.5 → NP_060518.1  protein mago nashi homolog 2 isoform 1

      See identical proteins and their annotated locations for NP_060518.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC021049, AF165518, BG533740, CD357202
      Consensus CDS
      CCDS8628.1
      UniProtKB/Swiss-Prot
      Q96A72
      UniProtKB/TrEMBL
      A0A023T6R1
      Related
      ENSP00000319240.2, ENST00000320756.7
      Conserved Domains (1) summary
      cd11295
      Location:6 → 148
      Mago_nashi; Mago nashi proteins, integral members of the exon junction complex

    RNA

    1. NR_135120.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC021049, BC000928, BG533740, CD357202
    2. NR_135121.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses an alternate splice site in the 5' region and contains an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC021049, BC000928, BG533740, BG539870

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      10599524..10613609 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047429058.1 → XP_047285014.1  protein mago nashi homolog 2 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      10472850..10486915 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054372386.1 → XP_054228361.1  protein mago nashi homolog 2 isoform X1

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