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    Y39B6A.3 Iron-sulfur cluster assembly 1 homolog, mitochondrial [ Caenorhabditis elegans ]

    Gene ID: 180262, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Y39B6A.3
    Official Full Name
    Iron-sulfur cluster assembly 1 homolog, mitochondrial
    Primary source
    WormBase:WBGene00012666
    Locus tag
    CELE_Y39B6A.3
    See related
    AllianceGenome:WB:WBGene00012666
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable 2 iron, 2 sulfur cluster binding activity. Predicted to be involved in iron-sulfur cluster assembly and protein maturation by iron-sulfur cluster transfer. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in multiple mitochondrial dysfunctions syndrome 5. Orthologous to human ISCA1 (iron-sulfur cluster assembly 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See Y39B6A.3 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    4
    Sequence:
    Chromosome: V; NC_003283.11 (19189245..19190013, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Homolog of Odr-2 (Two) Neighboring gene Serine/threonine specific protein phosphatases domain-containing protein;Serine/threonine-protein phosphatase 5 Neighboring gene Histidine-rich glycoprotein-like

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables iron-sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in iron-sulfur cluster assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in iron-sulfur cluster assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein maturation by iron-sulfur cluster transfer IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Iron-sulfur cluster assembly 1 homolog, mitochondrial
    NP_001123038.1
    • Confirmed by transcript evidence
    NP_741696.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      19189245..19190013 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001129566.4 → NP_001123038.1  Iron-sulfur cluster assembly 1 homolog, mitochondrial [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001123038.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A5HWB2
      Conserved Domains (1) summary
      TIGR00049
      Location:28 → 131
      TIGR00049; Iron-sulfur cluster assembly accessory protein

    2. NM_171606.6 → NP_741696.1  Iron-sulfur cluster assembly 1 homolog, mitochondrial [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741696.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9NES9
      Conserved Domains (1) summary
      TIGR00049
      Location:26 → 129
      TIGR00049; Iron-sulfur cluster assembly accessory protein
    Nucleotide Protein
    Heading Accession and Version

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