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    C47E8.4 Protein FAM50 homolog [ Caenorhabditis elegans ]

    Gene ID: 179970, updated on 9-Dec-2024

    Summary

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    Official Symbol
    C47E8.4
    Official Full Name
    Protein FAM50 homolog
    Primary source
    WormBase:WBGene00008143
    Locus tag
    CELE_C47E8.4
    See related
    AllianceGenome:WB:WBGene00008143
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in chromatin organization. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Armfield syndrome. Orthologous to human FAM50A (family with sequence similarity 50 member A) and FAM50B (family with sequence similarity 50 member B). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See C47E8.4 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    7
    Sequence:
    Chromosome: V; NC_003283.11 (14683698..14685485, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene Heat shock protein 90 Neighboring gene Secreted protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    2. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
    3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in chromatin organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Protein FAM50 homolog
    NP_001256609.1
    • Confirmed by transcript evidence
    NP_001256610.1
    • Confirmed by transcript evidence
    NP_001256611.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      14683698..14685485 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001269680.2 → NP_001256609.1  Protein FAM50 homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256609.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D5MCS3, D5MCS4, D5MCS5, Q18691
      Conserved Domains (1) summary
      pfam04921
      Location:132 → 318
      XAP5; circadian clock regulator

    2. NM_001269681.3 → NP_001256610.1  Protein FAM50 homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256610.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q18691
      Conserved Domains (1) summary
      pfam04921
      Location:1 → 178
      XAP5; XAP5, circadian clock regulator

    3. NM_001269682.3 → NP_001256611.1  Protein FAM50 homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256611.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q18691
      Conserved Domains (1) summary
      pfam04921
      Location:1 → 86
      XAP5; XAP5, circadian clock regulator
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q18691.3

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