manf-1 Mesencephalic astrocyte-derived neurotrophic factor homolog [Caenorhabditis elegans] - Gene

Summary

Official Symbol: manf-1
Official Full Name: Mesencephalic astrocyte-derived neurotrophic factor homolog
Primary source: WormBase:WBGene00021888
Locus tag: CELE_Y54G2A.23
See related: AllianceGenome:WB:WBGene00021888
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables sulfatide binding activity. Involved in developmental growth and regulation of response to endoplasmic reticulum stress. Predicted to be located in endoplasmic reticulum lumen and extracellular region. Predicted to be active in endoplasmic reticulum and extracellular space. Is expressed in several structures, including anus; excretory gland cell; pharynx; rectal valve cell; and somatic cell. Human ortholog(s) of this gene implicated in Parkinsonism; breast cancer; carcinoma (multiple); and pancreatic cancer. Orthologous to several human genes including CDNF (cerebral dopamine neurotrophic factor). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

The neurotrophic factor MANF regulates autophagy and lysosome function to promote proteostasis in Caenorhabditis elegans.
Title: The neurotrophic factor MANF regulates autophagy and lysosome function to promote proteostasis in Caenorhabditis elegans.
Sulfatide binding promotes cellular MANF uptake and cytoprotection from hypoxia-induced cell death.
Title: Conserved roles of C. elegans and human MANFs in sulfatide binding and cytoprotection.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables sulfatide binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in ATF6-mediated unfolded protein response	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in developmental growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dopaminergic neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron projection development	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of response to endoplasmic reticulum stress	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum lumen	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

Preferred Names: Mesencephalic astrocyte-derived neurotrophic factor homolog

NP_500273.2

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