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    F54H5.2 Protein kinase domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 186263, updated on 9-Dec-2024

    Summary

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    Official Symbol
    F54H5.2
    Official Full Name
    Protein kinase domain-containing protein
    Primary source
    WormBase:WBGene00018839
    Locus tag
    CELE_F54H5.2
    See related
    AllianceGenome:WB:WBGene00018839
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ATP binding activity and protein kinase activity. Predicted to be involved in protein phosphorylation. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 11. Orthologous to human TTBK1 (tau tubulin kinase 1) and TTBK2 (tau tubulin kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See F54H5.2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    6
    Sequence:
    Chromosome: II; NC_003280.10 (6627484..6629274)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Lipid-binding serum glycoprotein C-terminal domain-containing protein Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene VWFA domain-containing protein Neighboring gene non-specific serine/threonine protein kinase Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Protein kinase domain-containing protein
    NP_001300551.1
    • Confirmed by transcript evidence
    NP_001300552.1
    • Confirmed by transcript evidence
    NP_495347.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      6627484..6629274
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_062946.2 → NP_495347.1  Protein kinase domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495347.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      P91332
      Conserved Domains (2) summary
      PRK14907
      Location:317 → 422
      rplD; 50S ribosomal protein L4; Provisional
      cl21453
      Location:31 → 297
      PKc_like; Protein Kinases, catalytic domain

    2. NM_001313622.3 → NP_001300551.1  Protein kinase domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AUL1
      Conserved Domains (2) summary
      COG5116
      Location:51 → 157
      RPN2; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]
      cl21453
      Location:1 → 43
      PKc_like; Protein Kinases, catalytic domain

    3. NM_001313623.3 → NP_001300552.1  Protein kinase domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AWX6
      Conserved Domains (1) summary
      COG5116
      Location:11 → 117
      RPN2; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein
    Heading Accession and Version

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