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    Dstl1 dystonin like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 680875, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Dstl1provided by RGD
    Official Full Name
    dystonin like 1provided by RGD
    Primary source
    RGD:1587008
    See related
    EnsemblRapid:ENSRNOG00000023828 AllianceGenome:RGD:1587008
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable actin filament binding activity. Predicted to be involved in cytoskeleton organization; protein localization to microtubule plus-end; and regulation of microtubule polymerization or depolymerization. Predicted to be active in cytoplasm. Predicted to colocalize with microtubule plus-end and stress fiber. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 100.8), Brain (RPKM 17.8) and 1 other tissue See more
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    Genomic context

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    See Dstl1 in Genome Data Viewer
    Location:
    7q34
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (109718777..109736508, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (107838089..107847304, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (117180653..117187739, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102548315 Neighboring gene nuclear receptor binding protein 2 Neighboring gene epiplakin 1 Neighboring gene uncharacterized LOC134479927 Neighboring gene uncharacterized LOC102548374 Neighboring gene plectin Neighboring gene poly (ADP-ribose) polymerase family, member 10 Neighboring gene glutamate ionotropic receptor NMDA type subunit associated protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin crosslink formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule bundle formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to microtubule plus-end IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of microtubule polymerization or depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    colocalizes_with microtubule plus-end IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    colocalizes_with stress fiber IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein Dstl1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      109718777..109736508 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063264666.1 → XP_063120736.1  uncharacterized protein Dstl1 isoform X3

    2. XM_002729838.7 → XP_002729884.2  uncharacterized protein Dstl1 isoform X1

      See identical proteins and their annotated locations for XP_002729884.2

      UniProtKB/TrEMBL
      D4ABX7
      Related
      ENSRNOP00000014191.6, ENSRNOT00000014191.8
      Conserved Domains (2) summary
      cl02488
      Location:157 → 282
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl02524
      Location:672 → 700
      GAS2; Growth-Arrest-Specific Protein 2 Domain

    3. XM_017595384.3 → XP_017450873.1  uncharacterized protein Dstl1 isoform X2

    4. XM_039080532.2 → XP_038936460.1  uncharacterized protein Dstl1 isoform X4

    5. XM_063264667.1 → XP_063120737.1  uncharacterized protein Dstl1 isoform X5

      UniProtKB/TrEMBL
      A6HS62
    Nucleotide Protein Strain
    Heading Accession and Version

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