Arfrp1 ARF related protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Arfrp1provided by RGD
Official Full Name: ARF related protein 1provided by RGD
Primary source: RGD:621683
See related: EnsemblRapid:ENSRNOG00000013992 AllianceGenome:RGD:621683
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in protein localization to Golgi apparatus; protein transport; and retrograde transport, endosome to Golgi. Predicted to act upstream of or within gastrulation. Predicted to be located in membrane and trans-Golgi network. Predicted to be active in Golgi apparatus. Orthologous to human ARFRP1 (ADP ribosylation factor related protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 168.3), Lung (RPKM 146.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q43

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (188844013..188851473, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (168466351..168473960, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (176857667..176865105, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Golgi to plasma membrane protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in Golgi to plasma membrane protein transport	IEA Inferred from Electronic Annotation more info
involved_in Golgi to plasma membrane protein transport	ISO Inferred from Sequence Orthology more info
involved_in gastrulation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within gastrulation	ISO Inferred from Sequence Orthology more info
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to Golgi apparatus	IEA Inferred from Electronic Annotation more info
involved_in protein localization to Golgi apparatus	ISO Inferred from Sequence Orthology more info
involved_in retrograde transport, endosome to Golgi	IEA Inferred from Electronic Annotation more info
involved_in retrograde transport, endosome to Golgi	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network	IEA Inferred from Electronic Annotation more info
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ADP-ribosylation factor-related protein 1

Names: ADP-ribosylation factor related protein 1; ARP

NP_446432.1

EC 3.6.5.1

EC 3.6.5.2

EC 3.6.5.3

EC 3.6.5.4

XP_006235780.1

EC 3.6.5.1

EC 3.6.5.2

EC 3.6.5.3

EC 3.6.5.4

XP_038960051.2

EC 3.6.5.1

EC 3.6.5.2

EC 3.6.5.3

EC 3.6.5.4

XP_038960052.1

EC 3.6.5.1

EC 3.6.5.2

EC 3.6.5.3

EC 3.6.5.4

XP_063139078.1

EC 3.6.5.1

EC 3.6.5.2

EC 3.6.5.3

EC 3.6.5.4

XP_063139079.1

EC 3.6.5.1

EC 3.6.5.2

EC 3.6.5.3

EC 3.6.5.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001429718.1 → NP_001416647.1 ADP-ribosylation factor-related protein 1 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003
NM_001429719.1 → NP_001416648.1 ADP-ribosylation factor-related protein 1 isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003
NM_001429721.1 → NP_001416650.1 ADP-ribosylation factor-related protein 1 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

Q63055

UniProtKB/TrEMBL

A6KM17
NM_053980.3 → NP_446432.1 ADP-ribosylation factor-related protein 1 isoform 1

See identical proteins and their annotated locations for NP_446432.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

Q63055

UniProtKB/TrEMBL

A0A8L2QAM9, A6KM17

Conserved Domains (1) summary

cd04160
Location:19 → 186

Arfrp1; Arf-related protein 1 (Arfrp1)

RNA

NR_190776.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

188844013..188851473 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039104123.2 → XP_038960051.2 ADP-ribosylation factor-related protein 1 isoform X1
XM_006235718.4 → XP_006235780.1 ADP-ribosylation factor-related protein 1 isoform X4

Conserved Domains (1) summary

cd04160
Location:19 → 186

Arfrp1; Arf-related protein 1 (Arfrp1)
XM_063283008.1 → XP_063139078.1 ADP-ribosylation factor-related protein 1 isoform X3
XM_063283009.1 → XP_063139079.1 ADP-ribosylation factor-related protein 1 isoform X5
XM_039104124.2 → XP_038960052.1 ADP-ribosylation factor-related protein 1 isoform X2

Related

ENSRNOP00000019038.4, ENSRNOT00000019038.7

Conserved Domains (1) summary

cl38936
Location:34 → 136

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases