Slc35b4 solute carrier family 35 member B4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc35b4provided by RGD
Official Full Name: solute carrier family 35 member B4provided by RGD
Primary source: RGD:1308985
See related: EnsemblRapid:ENSRNOG00000008851 AllianceGenome:RGD:1308985
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable UDP-N-acetylglucosamine transmembrane transporter activity and UDP-xylose transmembrane transporter activity. Predicted to be involved in UDP-N-acetylglucosamine transmembrane transport and UDP-xylose transmembrane transport. Predicted to act upstream of or within regulation of gluconeogenesis. Predicted to be located in endoplasmic reticulum. Predicted to be active in Golgi membrane and endoplasmic reticulum membrane. Orthologous to human SLC35B4 (solute carrier family 35 member B4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 240.9), Brain (RPKM 104.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q22

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (63744188..63766200, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (62776993..62799013, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (61550995..61573003, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables UDP-N-acetylglucosamine transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables UDP-N-acetylglucosamine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables UDP-xylose transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables UDP-xylose transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in UDP-N-acetylglucosamine transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in UDP-N-acetylglucosamine transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in UDP-xylose transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of gluconeogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Golgi membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: nucleotide sugar transporter SLC35B4

Names: UDP-xylose and UDP-N-acetylglucosamine transporter; solute carrier family 35 (UDP-xylose/UDP-N-acetylglucosamine transporter), member B4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106590.1 → NP_001100060.1 nucleotide sugar transporter SLC35B4

See identical proteins and their annotated locations for NP_001100060.1

Status: PROVISIONAL

Source sequence(s)

CH473959

UniProtKB/TrEMBL

A0A8I5Y6Z8, A6IEL0, D3ZAN4

Related

ENSRNOP00000012179.4, ENSRNOT00000012179.7

Conserved Domains (1) summary

pfam08449
Location:2 → 314

UAA; UAA transporter family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

63744188..63766200 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039107290.2 → XP_038963218.1 nucleotide sugar transporter SLC35B4 isoform X1

UniProtKB/TrEMBL

A0A8I5Y6Z8

Conserved Domains (1) summary

pfam08449
Location:2 → 276

UAA; UAA transporter family