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    Tpd52l2 TPD52 like 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296480, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tpd52l2provided by RGD
    Official Full Name
    TPD52 like 2provided by RGD
    Primary source
    RGD:735167
    See related
    EnsemblRapid:ENSRNOG00000080504 AllianceGenome:RGD:735167
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein homodimerization activity. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in cytoplasm. Orthologous to human TPD52L2 (TPD52 like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 161.8), Muscle (RPKM 155.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tpd52l2 in Genome Data Viewer
    Location:
    3q43
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (188972321..188995721)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (168598449..168618201)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (176989333..177009425)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene zinc finger and BTB domain containing 46 Neighboring gene RNA, U6 small nuclear 663 Neighboring gene uncharacterized LOC120101834 Neighboring gene uncharacterized LOC102548047 Neighboring gene abhydrolase domain containing 16B Neighboring gene ribosomal protein L34-like2 Neighboring gene DnaJ heat shock protein family (Hsp40) member C5 Neighboring gene uridine-cytidine kinase 1-like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. D53 (TPD52L1) is a cell cycle-regulated protein maximally expressed at the G2-M transition in breast cancer cells. Boutros R, et al. Exp Cell Res, 2005 Oct 15. PMID 16112108
    2. Cytokine-induced down-regulation of zfm1/splicing factor-1 promotes smooth muscle cell proliferation. Cattaruzza M, et al. J Biol Chem, 2002 Feb 22. PMID 11748220
    3. Identification of homo- and heteromeric interactions between members of the breast carcinoma-associated D52 protein family using the yeast two-hybrid system. Byrne JA, et al. Oncogene, 1998 Feb 19. PMID 9484778
    4. Phosphorylation and degradation of tomosyn-2 de-represses insulin secretion. Bhatnagar S, et al. J Biol Chem, 2014 Sep 5. PMID 25002582, Free PMC Article
    5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC73020

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    tumor protein D54
    Names
    tumor protein D52-like 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001431560.1 → NP_001418489.1  tumor protein D54 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6KM05, A6KM08

    2. NM_001431561.1 → NP_001418490.1  tumor protein D54 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    3. NM_001431562.1 → NP_001418491.1  tumor protein D54 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6KM08

    4. NM_001431563.1 → NP_001418492.1  tumor protein D54 isoform 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6KM07, A6KM08

    5. NM_001431564.1 → NP_001418493.1  tumor protein D54 isoform 6

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6KM08

    6. NM_001431565.1 → NP_001418494.1  tumor protein D54 isoform 7

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6KM08

    7. NM_001431566.1 → NP_001418495.1  tumor protein D54 isoform 8

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6KM08

    8. NM_001431567.1 → NP_001418496.1  tumor protein D54 isoform 9

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6KM00, A6KM08

    9. NM_001431568.1 → NP_001418497.1  tumor protein D54 isoform 10

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    10. NM_198744.3 → NP_942039.1  tumor protein D54 isoform 2

      See identical proteins and their annotated locations for NP_942039.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q6PCT3
      UniProtKB/TrEMBL
      A6KM06, A6KM08
      Conserved Domains (1) summary
      pfam04201
      Location:55 → 211
      TPD52; tumor protein D52 family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      188972321..188995721
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006235761.4 → XP_006235823.1  tumor protein D54 isoform X13

      See identical proteins and their annotated locations for XP_006235823.1

      UniProtKB/TrEMBL
      A6KM02, A6KM08
      Conserved Domains (1) summary
      pfam04201
      Location:55 → 177
      TPD52; tumor protein D52 family

    2. XM_006235759.5 → XP_006235821.1  tumor protein D54 isoform X7

      Related
      ENSRNOP00000108826.1, ENSRNOT00000141925.1
      Conserved Domains (1) summary
      pfam04201
      Location:55 → 197
      TPD52; tumor protein D52 family

    3. XM_039104697.2 → XP_038960625.1  tumor protein D54 isoform X1

      Related
      ENSRNOP00000080130.2, ENSRNOT00000114740.2
      Conserved Domains (1) summary
      pfam04201
      Location:55 → 221
      TPD52; tumor protein D52 family

    4. XM_006235754.5 → XP_006235816.1  tumor protein D54 isoform X2

      Conserved Domains (1) summary
      pfam04201
      Location:55 → 220
      TPD52; tumor protein D52 family

    5. XM_039104698.2 → XP_038960626.1  tumor protein D54 isoform X3

    6. XM_063283451.1 → XP_063139521.1  tumor protein D54 isoform X18

    7. XM_063283448.1 → XP_063139518.1  tumor protein D54 isoform X14

      UniProtKB/TrEMBL
      A6KM08

    8. XM_063283449.1 → XP_063139519.1  tumor protein D54 isoform X16

      UniProtKB/TrEMBL
      A6KM08

    9. XM_017591623.3 → XP_017447112.1  tumor protein D54 isoform X19

    10. XM_039104700.2 → XP_038960628.1  tumor protein D54 isoform X6

      UniProtKB/TrEMBL
      A6KM08
      Conserved Domains (1) summary
      pfam04201
      Location:32 → 198
      TPD52; tumor protein D52 family

    11. XM_063283446.1 → XP_063139516.1  tumor protein D54 isoform X8

      UniProtKB/TrEMBL
      A6KM01, A6KM08

    12. XM_063283447.1 → XP_063139517.1  tumor protein D54 isoform X11

    13. XM_039104699.2 → XP_038960627.1  tumor protein D54 isoform X4

      Conserved Domains (1) summary
      pfam04201
      Location:55 → 201
      TPD52; tumor protein D52 family

    14. XM_039104702.2 → XP_038960630.1  tumor protein D54 isoform X12

      Conserved Domains (1) summary
      pfam04201
      Location:32 → 188
      TPD52; tumor protein D52 family

    15. XM_006235757.5 → XP_006235819.1  tumor protein D54 isoform X5

      See identical proteins and their annotated locations for XP_006235819.1

      UniProtKB/TrEMBL
      A6KM04
      Conserved Domains (1) summary
      pfam04201
      Location:55 → 200
      TPD52; tumor protein D52 family

    16. XM_039104701.2 → XP_038960629.1  tumor protein D54 isoform X9

      Conserved Domains (1) summary
      pfam04201
      Location:55 → 192
      TPD52; tumor protein D52 family

    17. XM_008762500.3 → XP_008760722.1  tumor protein D54 isoform X17

      UniProtKB/TrEMBL
      A6KM08
      Conserved Domains (1) summary
      pfam04201
      Location:32 → 154
      TPD52; Tumour protein D52 family

    18. XM_006235760.5 → XP_006235822.1  tumor protein D54 isoform X10

      See identical proteins and their annotated locations for XP_006235822.1

      UniProtKB/TrEMBL
      A6KM03, A6KM08
      Conserved Domains (1) summary
      pfam04201
      Location:55 → 191
      TPD52; tumor protein D52 family

    19. XM_039104703.2 → XP_038960631.1  tumor protein D54 isoform X15

      Conserved Domains (1) summary
      pfam04201
      Location:32 → 174
      TPD52; tumor protein D52 family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PCT3.1 GenPept UniProtKB/Swiss-Prot:Q6PCT3

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