Apip APAF1 interacting protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Apipprovided by RGD
Official Full Name: APAF1 interacting proteinprovided by RGD
Primary source: RGD:1564562
See related: EnsemblRapid:ENSRNOG00000007446 AllianceGenome:RGD:1564562
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1564562
Summary: Predicted to enable identical protein binding activity; methylthioribulose 1-phosphate dehydratase activity; and zinc ion binding activity. Predicted to be involved in several processes, including L-methionine salvage from methylthioadenosine; protein homotetramerization; and pyroptotic inflammatory response. Predicted to act upstream of or within negative regulation of apoptotic process. Predicted to be located in endomembrane system. Predicted to be active in cytoplasm. Orthologous to human APIP (APAF1 interacting protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 40.0), Kidney (RPKM 28.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q32

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (109886919..109913295)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (89431964..89458000)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (92969128..92998104)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AU047000 (e-PCR)
- UniSTS:110939

RH135014 (e-PCR)
- UniSTS:218291

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables methylthioribulose 1-phosphate dehydratase activity	IBA Inferred from Biological aspect of Ancestor more info
enables methylthioribulose 1-phosphate dehydratase activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in L-methionine salvage from methylthioadenosine	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-methionine salvage from methylthioadenosine	IEA Inferred from Electronic Annotation more info
involved_in L-methionine salvage from methylthioadenosine	ISO Inferred from Sequence Orthology more info
acts_upstream_of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in protein homotetramerization	ISO Inferred from Sequence Orthology more info
involved_in pyroptotic inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in endomembrane system	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: methylthioribulose-1-phosphate dehydratase

Names: probable methylthioribulose-1-phosphate dehydratase

NP_001099962.2

EC 4.2.1.109

XP_038960457.1

EC 4.2.1.109

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106492.2 → NP_001099962.2 methylthioribulose-1-phosphate dehydratase

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A6HNQ5, D3ZUI1

Related

ENSRNOP00000009797.6, ENSRNOT00000009797.8

Conserved Domains (1) summary

TIGR03328
Location:27 → 225

salvage_mtnB; methylthioribulose-1-phosphate dehydratase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

109886919..109913295

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039104529.2 → XP_038960457.1 methylthioribulose-1-phosphate dehydratase isoform X1

UniProtKB/TrEMBL

A6HNQ6

Conserved Domains (1) summary

cl00214
Location:1 → 154

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...