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    Dnajc18 DnaJ heat shock protein family (Hsp40) member C18 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291677, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dnajc18provided by RGD
    Official Full Name
    DnaJ heat shock protein family (Hsp40) member C18provided by RGD
    Primary source
    RGD:1310237
    See related
    EnsemblRapid:ENSRNOG00000019995 AllianceGenome:RGD:1310237
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1310237
    Summary
    Predicted to enable Hsp70 protein binding activity. Predicted to be involved in cellular response to misfolded protein and chaperone cofactor-dependent protein refolding. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human DNAJC18 (DnaJ heat shock protein family (Hsp40) member C18). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 319.0), Brain (RPKM 172.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dnajc18 in Genome Data Viewer
    Location:
    18p11
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (27543438..27577535, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (27269350..27303453, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (28466892..28501013, complement)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene proline-rich basic protein 1 Neighboring gene spermatogenesis associated 24 Neighboring gene endothelial cell surface expressed chemotaxis and apoptosis regulator Neighboring gene small integral membrane protein 33

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables Hsp70 protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to misfolded protein IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chaperone cofactor-dependent protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    dnaJ homolog subfamily C member 18
    Names
    DnaJ (Hsp40) homolog, subfamily C, member 18

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013887.2 → NP_001013909.1  dnaJ homolog subfamily C member 18 isoform 1

      See identical proteins and their annotated locations for NP_001013909.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      A0A8I5ZNW9, Q6AXW3
      Related
      ENSRNOP00000079625.2, ENSRNOT00000097174.2
      Conserved Domains (2) summary
      pfam00226
      Location:41 → 102
      DnaJ; DnaJ domain
      pfam09320
      Location:209 → 308
      DUF1977; Domain of unknown function (DUF1977)

    2. NM_001398603.1 → NP_001385532.1  dnaJ homolog subfamily C member 18 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      A0A8I5ZNW9, F7F826, Q0H8V1
      Related
      ENSRNOP00000027194.6, ENSRNOT00000027194.8
      Conserved Domains (2) summary
      PRK14298
      Location:81 → 182
      PRK14298; chaperone protein DnaJ; Provisional
      pfam09320
      Location:249 → 349
      DUF1977; Domain of unknown function (DUF1977)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      27543438..27577535 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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