Actr2 actin related protein 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Actr2provided by RGD
Official Full Name: actin related protein 2provided by RGD
Primary source: RGD:1310826
See related: EnsemblRapid:ENSRNOG00000004959 AllianceGenome:RGD:1310826
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables cytoskeletal protein binding activity. Involved in several processes, including cellular response to trichostatin A; positive regulation of dendritic spine morphogenesis; and response to ethanol. Located in lamellipodium and podosome core. Is active in postsynapse. Orthologous to human ACTR2 (actin related protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Spleen (RPKM 1054.0), Thymus (RPKM 752.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14q22

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (98500119..98535092, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (94296443..94333735, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (104338486..104375840, complement)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Impairments of learning and memory function in the acute phase after mild traumatic brain injury may be induced by a reduction in Arp2 expression.
Title: Relationship between learning and memory deficits and Arp2 expression in the hippocampus in rats with traumatic brain injury.
PICK1 is a negative regulator of Arp2/3-mediated actin polymerization that is critical for a specific form of vesicle trafficking, and also for the development of neuronal architecture
Title: Inhibition of Arp2/3-mediated actin polymerization by PICK1 regulates neuronal morphology and AMPA receptor endocytosis.
in Rous sarcoma virus-transformed cells, changes in the balance between PAK1/2-regulated caldesmon and the Arp2/3 complex govern the formation of podosomes
Title: Changes in the balance between caldesmon regulated by p21-activated kinases and the Arp2/3 complex govern podosome formation.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH139107 (e-PCR)
- UniSTS:221193

AA818437 (e-PCR)
- UniSTS:249714

RH144671 (e-PCR)
- UniSTS:233916

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables actin binding	IEA Inferred from Electronic Annotation more info
contributes_to actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
contributes_to actin filament binding	ISO Inferred from Sequence Orthology more info
enables cytoskeletal protein binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural constituent of cytoskeleton	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Arp2/3 complex-mediated actin nucleation	IBA Inferred from Biological aspect of Ancestor more info
involved_in Arp2/3 complex-mediated actin nucleation	ISO Inferred from Sequence Orthology more info
involved_in Arp2/3 complex-mediated actin nucleation	ISS Inferred from Sequence or Structural Similarity more info
involved_in actin cytoskeleton organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in associative learning	IEP Inferred from Expression Pattern more info	PubMed
involved_in asymmetric cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within asymmetric cell division	ISO Inferred from Sequence Orthology more info
involved_in cellular response to trichostatin A	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to type II interferon	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to type II interferon	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in cytosolic transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cytosolic transport	ISO Inferred from Sequence Orthology more info
involved_in establishment or maintenance of cell polarity	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within establishment or maintenance of cell polarity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within meiotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in meiotic chromosome movement towards spindle pole	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within meiotic chromosome movement towards spindle pole	ISO Inferred from Sequence Orthology more info
involved_in meiotic cytokinesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within meiotic cytokinesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendritic spine morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of double-strand break repair via homologous recombination	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of lamellipodium assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
NOT involved_in regulation of double-strand break repair via nonhomologous end joining	ISO Inferred from Sequence Orthology more info
NOT involved_in regulation of double-strand break repair via nonhomologous end joining	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to immobilization stress	IEP Inferred from Expression Pattern more info	PubMed
involved_in spindle localization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within spindle localization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of Arp2/3 protein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Arp2/3 protein complex	ISO Inferred from Sequence Orthology more info
part_of Arp2/3 protein complex	ISS Inferred from Sequence or Structural Similarity more info
located_in actin cap	IEA Inferred from Electronic Annotation more info
located_in actin cap	ISO Inferred from Sequence Orthology more info
is_active_in cell cortex	IBA Inferred from Biological aspect of Ancestor more info
located_in cell cortex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in lamellipodium	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in podosome core	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynapse	EXP Inferred from Experiment more info	PubMed
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
located_in site of double-strand break	ISO Inferred from Sequence Orthology more info
located_in site of double-strand break	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: actin-related protein 2

Names: ARP2 actin related protein 2 homolog; actin-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001009268.1 → NP_001009268.1 actin-related protein 2

See identical proteins and their annotated locations for NP_001009268.1

Status: PROVISIONAL

Source sequence(s)

BC088442

UniProtKB/Swiss-Prot

Q5M7U6

UniProtKB/TrEMBL

A0A8I6GBC3, A6JQ13

Related

ENSRNOP00000006607.5, ENSRNOT00000006607.7

Conserved Domains (2) summary

smart00268
Location:6 → 388

ACTIN; Actin

cl17037
Location:1 → 382

NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily