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    Mavs mitochondrial antiviral signaling protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311430, updated on 3-Dec-2024

    Summary

    Official Symbol
    Mavsprovided by RGD
    Official Full Name
    mitochondrial antiviral signaling proteinprovided by RGD
    Primary source
    RGD:1359371
    See related
    EnsemblRapid:ENSRNOG00000025295 AllianceGenome:RGD:1359371
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Visa
    Summary
    Predicted to enable several functions, including CARD domain binding activity; RIG-I binding activity; and molecular condensate scaffold activity. Predicted to be involved in several processes, including positive regulation of cytokine production; regulation of DNA-templated transcription; and regulation of defense response. Predicted to act upstream of or within RIG-I signaling pathway and positive regulation of type I interferon production. Predicted to be located in mitochondrion and peroxisomal membrane. Predicted to be active in mitochondrial outer membrane. Orthologous to human MAVS (mitochondrial antiviral signaling protein). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 135.8), Kidney (RPKM 103.6) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Mavs in Genome Data Viewer
    Location:
    3q36
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (138904673..138919129)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (118451650..118466094)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (123776147..123790572)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene cell division cycle 25B Neighboring gene adaptor related protein complex 5 subunit sigma 1 Neighboring gene uncharacterized LOC134486155 Neighboring gene pantothenate kinase 2 Neighboring gene microRNA 103a-2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Markers

    Clone Names

    • MGC93707

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables CARD domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RIG-I binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables molecular condensate scaffold activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables signaling adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within RIG-I signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in activation of innate immune response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in activation of innate immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in antiviral innate immune response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to exogenous dsRNA ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to exogenous dsRNA ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cytoplasmic pattern recognition receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in defense response to bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in defense response to bacterium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_positive_effect innate immune response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in innate immune response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in innate immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of type I interferon-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of viral genome replication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of IP-10 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of NLRP3 inflammasome complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in positive regulation of chemokine (C-C motif) ligand 5 production ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of defense response to virus by host ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of defense response to virus by host ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of defense response to virus by host ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within positive regulation of interferon-alpha production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interferon-alpha production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interferon-alpha production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within positive regulation of interferon-beta production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interferon-beta production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interferon-beta production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within positive regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interleukin-6 production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of interleukin-8 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of myeloid dendritic cell cytokine production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of myeloid dendritic cell cytokine production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of response to cytokine stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of response to cytokine stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of tumor necrosis factor production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within positive regulation of type I interferon production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of type I interferon production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of type I interferon-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of peroxisome organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in peroxisomal membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    mitochondrial antiviral-signaling protein
    Names
    IPS-1
    interferon beta promoter stimulator protein 1
    virus-induced signaling adaptor
    virus-induced-signaling adapter

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005556.1NP_001005556.1  mitochondrial antiviral-signaling protein

      See identical proteins and their annotated locations for NP_001005556.1

      Status: PROVISIONAL

      Source sequence(s)
      BC081869
      UniProtKB/Swiss-Prot
      Q66HG9
      UniProtKB/TrEMBL
      A0A8L2QH64, A6HQD4
      Conserved Domains (2) summary
      PHA03247
      Location:65468
      PHA03247; large tegument protein UL36; Provisional
      cd08811
      Location:393
      CARD_IPS1; Caspase activation and recruitment domain (CARD) found in IPS-1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      138904673..138919129
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063283781.1XP_063139851.1  mitochondrial antiviral-signaling protein isoform X2

      UniProtKB/TrEMBL
      A0A8L2QH64
    2. XM_006235034.4XP_006235096.1  mitochondrial antiviral-signaling protein isoform X1

      See identical proteins and their annotated locations for XP_006235096.1

      UniProtKB/Swiss-Prot
      Q66HG9
      UniProtKB/TrEMBL
      A0A8L2QH64, A6HQD4
      Conserved Domains (2) summary
      PHA03247
      Location:65468
      PHA03247; large tegument protein UL36; Provisional
      cd08811
      Location:393
      CARD_IPS1; Caspase activation and recruitment domain (CARD) found in IPS-1
    3. XM_063283775.1XP_063139845.1  mitochondrial antiviral-signaling protein isoform X1

      UniProtKB/Swiss-Prot
      Q66HG9
      UniProtKB/TrEMBL
      A0A8L2QH64, A6HQD4
    4. XM_006235035.5XP_006235097.1  mitochondrial antiviral-signaling protein isoform X1

      See identical proteins and their annotated locations for XP_006235097.1

      UniProtKB/Swiss-Prot
      Q66HG9
      UniProtKB/TrEMBL
      A0A8L2QH64, A6HQD4
      Conserved Domains (2) summary
      PHA03247
      Location:65468
      PHA03247; large tegument protein UL36; Provisional
      cd08811
      Location:393
      CARD_IPS1; Caspase activation and recruitment domain (CARD) found in IPS-1
    5. XM_006235036.4XP_006235098.1  mitochondrial antiviral-signaling protein isoform X1

      See identical proteins and their annotated locations for XP_006235098.1

      UniProtKB/Swiss-Prot
      Q66HG9
      UniProtKB/TrEMBL
      A0A8L2QH64, A6HQD4
      Related
      ENSRNOP00000073053.1, ENSRNOT00000090764.3
      Conserved Domains (2) summary
      PHA03247
      Location:65468
      PHA03247; large tegument protein UL36; Provisional
      cd08811
      Location:393
      CARD_IPS1; Caspase activation and recruitment domain (CARD) found in IPS-1
    6. XM_063283779.1XP_063139849.1  mitochondrial antiviral-signaling protein isoform X2

      UniProtKB/TrEMBL
      A0A8L2QH64
    7. XM_063283776.1XP_063139846.1  mitochondrial antiviral-signaling protein isoform X1

      UniProtKB/Swiss-Prot
      Q66HG9
      UniProtKB/TrEMBL
      A0A8L2QH64, A6HQD4
    8. XM_039105011.2XP_038960939.1  mitochondrial antiviral-signaling protein isoform X3

      Conserved Domains (2) summary
      PHA03247
      Location:10298
      PHA03247; large tegument protein UL36; Provisional
      NF033645
      Location:98240
      pilus_FilE; putative pilus assembly protein FilE
    9. XM_063283778.1XP_063139848.1  mitochondrial antiviral-signaling protein isoform X1

      UniProtKB/Swiss-Prot
      Q66HG9
      UniProtKB/TrEMBL
      A0A8L2QH64, A6HQD4
    10. XM_006235037.5XP_006235099.1  mitochondrial antiviral-signaling protein isoform X3

      Conserved Domains (2) summary
      PHA03247
      Location:10298
      PHA03247; large tegument protein UL36; Provisional
      NF033645
      Location:98240
      pilus_FilE; putative pilus assembly protein FilE
    11. XM_063283782.1XP_063139852.1  mitochondrial antiviral-signaling protein isoform X4

    12. XM_063283780.1XP_063139850.1  mitochondrial antiviral-signaling protein isoform X2

      UniProtKB/TrEMBL
      A0A8L2QH64
    13. XM_063283774.1XP_063139844.1  mitochondrial antiviral-signaling protein isoform X1

      UniProtKB/Swiss-Prot
      Q66HG9
      UniProtKB/TrEMBL
      A0A8L2QH64, A6HQD4