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    Zfp217 zinc finger protein 217 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311764, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfp217provided by RGD
    Official Full Name
    zinc finger protein 217provided by RGD
    Primary source
    RGD:1308451
    See related
    EnsemblRapid:ENSRNOG00000021787 AllianceGenome:RGD:1308451
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Znf217
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in mitochondrion and nuclear speck. Predicted to be part of histone deacetylase complex. Predicted to be active in nucleus. Orthologous to human ZNF217 (zinc finger protein 217). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 197.2), Thymus (RPKM 130.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zfp217 in Genome Data Viewer
    Location:
    3q42
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (179309178..179349853, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (158890464..158931148, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (166981419..167022349, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene teashirt zinc finger homeobox 2 Neighboring gene uncharacterized LOC134486490 Neighboring gene uncharacterized LOC120101802 Neighboring gene U2 spliceosomal RNA Neighboring gene uncharacterized LOC108350531 Neighboring gene uncharacterized LOC102547159

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A candidate pathogenic gene, zinc finger gene 217 (ZNF217), may contribute to polycystic ovary syndrome through prostaglandin E2. Zhai J, et al. Acta Obstet Gynecol Scand, 2020 Jan. PMID 31454071
    2. Biochemical characterization of the zinc-finger protein 217 transcriptional repressor complex: identification of a ZNF217 consensus recognition sequence. Cowger JJ, et al. Oncogene, 2007 May 17. PMID 17130829
    3. Specific recognition of ZNF217 and other zinc finger proteins at a surface groove of C-terminal binding proteins. Quinlan KG, et al. Mol Cell Biol, 2006 Nov. PMID 16940172, Free PMC Article
    4. Genome analysis identifies the p15ink4b tumor suppressor as a direct target of the ZNF217/CoREST complex. Thillainadesan G, et al. Mol Cell Biol, 2008 Oct. PMID 18625718, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PCOS-like rats presented decreased zinc finger gene 217 (Zfp217) and cytochrome P450 family 19 subfamily a member 1 (Cyp19a1) mRNA expression with an increased Cox2 expression in GCs.
      Title: A candidate pathogenic gene, zinc finger gene 217 (ZNF217), may contribute to polycystic ovary syndrome through prostaglandin E2.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription cis-regulatory region binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of histone deacetylase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 217

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107813.2 → NP_001101283.1  zinc finger protein 217

      See identical proteins and their annotated locations for NP_001101283.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6JXS1, D4AB75
      Related
      ENSRNOP00000070336.1, ENSRNOT00000081593.3
      Conserved Domains (5) summary
      sd00017
      Location:123 → 143
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:480 → 500
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:479 → 500
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:492 → 517
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:506 → 530
      zf-H2C2_5; C2H2-type zinc-finger domain

    2. NM_001434163.1 → NP_001421092.1  zinc finger protein 217

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6JXS1, D4AB75

    3. NM_001434164.1 → NP_001421093.1  zinc finger protein 217

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6JXS1, D4AB75

    4. NM_001434165.1 → NP_001421094.1  zinc finger protein 217

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6JXS1, D4AB75

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      179309178..179349853 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017591806.3 → XP_017447295.1  zinc finger protein 217 isoform X1

      Conserved Domains (5) summary
      sd00017
      Location:123 → 143
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:480 → 500
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:479 → 500
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:492 → 517
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:506 → 530
      zf-H2C2_5; C2H2-type zinc-finger domain

    2. XM_017591810.3 → XP_017447299.1  zinc finger protein 217 isoform X1

      Conserved Domains (5) summary
      sd00017
      Location:123 → 143
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:480 → 500
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:479 → 500
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:492 → 517
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:506 → 530
      zf-H2C2_5; C2H2-type zinc-finger domain

    3. XM_017591808.3 → XP_017447297.1  zinc finger protein 217 isoform X1

      UniProtKB/TrEMBL
      A6JXS1, D4AB75
      Conserved Domains (5) summary
      sd00017
      Location:123 → 143
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:480 → 500
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:479 → 500
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:492 → 517
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:506 → 530
      zf-H2C2_5; C2H2-type zinc-finger domain

    4. XM_017591809.3 → XP_017447298.1  zinc finger protein 217 isoform X1

      UniProtKB/TrEMBL
      A6JXS1, D4AB75
      Conserved Domains (5) summary
      sd00017
      Location:123 → 143
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:480 → 500
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:479 → 500
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:492 → 517
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:506 → 530
      zf-H2C2_5; C2H2-type zinc-finger domain

    5. XM_039105172.2 → XP_038961100.1  zinc finger protein 217 isoform X1

      UniProtKB/TrEMBL
      A6JXS1, D4AB75
      Conserved Domains (5) summary
      sd00017
      Location:123 → 143
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:480 → 500
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:479 → 500
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:492 → 517
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:506 → 530
      zf-H2C2_5; C2H2-type zinc-finger domain

    6. XM_017591813.3 → XP_017447302.1  zinc finger protein 217 isoform X1

      Conserved Domains (5) summary
      sd00017
      Location:123 → 143
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:480 → 500
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:479 → 500
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:492 → 517
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:506 → 530
      zf-H2C2_5; C2H2-type zinc-finger domain

    7. XM_063283913.1 → XP_063139983.1  zinc finger protein 217 isoform X2

      Related
      ENSRNOP00000107378.1, ENSRNOT00000142762.1

    8. XM_017591815.3 → XP_017447304.1  zinc finger protein 217 isoform X1

      UniProtKB/TrEMBL
      A6JXS1, D4AB75
      Conserved Domains (5) summary
      sd00017
      Location:123 → 143
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:480 → 500
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:479 → 500
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:492 → 517
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:506 → 530
      zf-H2C2_5; C2H2-type zinc-finger domain

    9. XM_017591816.3 → XP_017447305.1  zinc finger protein 217 isoform X1

      UniProtKB/TrEMBL
      A6JXS1, D4AB75
      Conserved Domains (5) summary
      sd00017
      Location:123 → 143
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:480 → 500
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:479 → 500
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:492 → 517
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:506 → 530
      zf-H2C2_5; C2H2-type zinc-finger domain

    10. XM_039105173.2 → XP_038961101.1  zinc finger protein 217 isoform X1

      UniProtKB/TrEMBL
      A6JXS1, D4AB75
      Conserved Domains (5) summary
      sd00017
      Location:123 → 143
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:480 → 500
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:479 → 500
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:492 → 517
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:506 → 530
      zf-H2C2_5; C2H2-type zinc-finger domain

    11. XM_017591814.3 → XP_017447303.1  zinc finger protein 217 isoform X1

      UniProtKB/TrEMBL
      A6JXS1, D4AB75
      Conserved Domains (5) summary
      sd00017
      Location:123 → 143
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:480 → 500
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:479 → 500
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:492 → 517
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:506 → 530
      zf-H2C2_5; C2H2-type zinc-finger domain

    12. XM_039105174.2 → XP_038961102.1  zinc finger protein 217 isoform X1

      UniProtKB/TrEMBL
      A6JXS1, D4AB75
      Conserved Domains (5) summary
      sd00017
      Location:123 → 143
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:480 → 500
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:479 → 500
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:492 → 517
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:506 → 530
      zf-H2C2_5; C2H2-type zinc-finger domain

    13. XM_017591812.3 → XP_017447301.1  zinc finger protein 217 isoform X1

      Conserved Domains (5) summary
      sd00017
      Location:123 → 143
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:480 → 500
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:479 → 500
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:492 → 517
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:506 → 530
      zf-H2C2_5; C2H2-type zinc-finger domain
    Nucleotide Protein Strain
    Heading Accession and Version

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