U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Olr59 olfactory receptor 59 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 170816, updated on 9-Dec-2024

    Summary

    Official Symbol
    Olr59provided by RGD
    Official Full Name
    olfactory receptor 59provided by RGD
    Primary source
    RGD:628858
    See related
    EnsemblRapid:ENSRNOG00000018606 AllianceGenome:RGD:628858
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RA1c; Olfr78; Or51e2
    Summary
    Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in Liver (RPKM 32.2), Kidney (RPKM 11.6) and 6 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Olr59 in Genome Data Viewer
    Location:
    1q32
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (166604972..166639634, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (157193051..157227707, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (167906030..167940688, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 51 subfamily A member 25 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene olfactory receptor family 51 subfamily F member 23B, pseudogene 1 Neighboring gene olfactory receptor family 51 subfamily F member 5 Neighboring gene olfactory receptor family 51 subfamily F member 23C Neighboring gene olfactory receptor pseudogene 55

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nuclear steroid receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nuclear steroid receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables nuclear steroid receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables olfactory receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables olfactory receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables olfactory receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables olfactory receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables signaling receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables signaling receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to fatty acid IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to fatty acid ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to fatty acid ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in detection of chemical stimulus involved in sensory perception of smell IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in melanocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in melanocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in melanocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in melanocyte proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in melanocyte proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in melanocyte proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of blood pressure IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of blood pressure ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of renin secretion into blood stream IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of renin secretion into blood stream ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of renin secretion into blood stream ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in steroid hormone receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in steroid hormone receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in steroid hormone receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in early endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in early endosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in early endosome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    olfactory receptor 51E2
    Names
    G-protein coupled receptor RA1c
    olfactory receptor 78

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173293.2NP_775415.2  olfactory receptor 51E2

      Status: REVIEWED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      O88628
      UniProtKB/TrEMBL
      A6I763, G3V8E6
      Conserved Domains (1) summary
      cd15222
      Location:24298
      7tmA_OR51-like; olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      166604972..166639634 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008759671.2XP_008757893.1  olfactory receptor 51E2 isoform X1

      See identical proteins and their annotated locations for XP_008757893.1

      UniProtKB/Swiss-Prot
      O88628
      UniProtKB/TrEMBL
      A6I763, G3V8E6
      Conserved Domains (1) summary
      cd15222
      Location:24298
      7tmA_OR51-like; olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
    2. XM_008759669.4XP_008757891.1  olfactory receptor 51E2 isoform X1

      See identical proteins and their annotated locations for XP_008757891.1

      UniProtKB/Swiss-Prot
      O88628
      UniProtKB/TrEMBL
      A6I763, G3V8E6
      Related
      ENSRNOP00000105716.1, ENSRNOT00000169520.1
      Conserved Domains (1) summary
      cd15222
      Location:24298
      7tmA_OR51-like; olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
    3. XM_008759670.4XP_008757892.1  olfactory receptor 51E2 isoform X1

      See identical proteins and their annotated locations for XP_008757892.1

      UniProtKB/Swiss-Prot
      O88628
      UniProtKB/TrEMBL
      A6I763, G3V8E6
      Conserved Domains (1) summary
      cd15222
      Location:24298
      7tmA_OR51-like; olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors