Mzb1 marginal zone B and B1 cell-specific protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mzb1provided by RGD
Official Full Name: marginal zone B and B1 cell-specific proteinprovided by RGD
Primary source: RGD:1310251
See related: EnsemblRapid:ENSRNOG00000022009 AllianceGenome:RGD:1310251
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Pacap; pERp1; RGD1310251
Summary: Predicted to be involved in several processes, including integrin activation; positive regulation of immunoglobulin production; and regulation of B cell proliferation. Predicted to be located in endoplasmic reticulum lumen. Predicted to be part of endoplasmic reticulum chaperone complex. Predicted to be active in extracellular region. Orthologous to human MZB1 (marginal zone B and B1 cell specific protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 280.1), Thymus (RPKM 120.7) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 18p11

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (27513087..27515148, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (27238999..27241060, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (28436546..28438607, complement)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

It is evident that PACAP-induced prodynorphin mRNA expression is mediated by the activation of the protein kinase A (PKA) pathway.
Title: Pituitary adenylate cyclase-activating polypeptide (PACAP) is an upstream regulator of prodynorphin mRNA expression in neurons.
VIP and CRF, originating from interneurons, and PACAP, expressed mainly by pyramidal cells, finely tune the excitability and gene expression in the neocortical network
Title: VIP, CRF, and PACAP act at distinct receptors to elicit different cAMP/PKA dynamics in the neocortex.
Data suggest that exogenous PACAP is able to counteract NMDA-induced toxicity, and that endogenous PACAP exerts a neuroprotective effect in the retina.
Title: Neuroprotective effect of PACAP against NMDA-induced retinal damage in the mouse.
Results indicate that lack of pancreatic PACAP did not aggravate, but rather ameliorated, cerulein-induced pancreatitis.
Title: Cerulein-induced acute pancreatitis in PACAP knockout mice.
These results suggest that PACAP exerts anti-inflammatory, particularly edema-inhibiting effects in allergic contact dermatitis.
Title: Pituitary adenylate cyclase-activating polypeptide deficiency enhances oxazolone-induced allergic contact dermatitis in mice.
These data indicate that islet-produced PACAP protects beta-cells from deteriorating action of high glucose and palmitate at least partly by blocking the elevation of UCP2, suggesting an anti-diabetic role for PACAP.
Title: Intra-islet PACAP protects pancreatic β-cells against glucotoxicity and lipotoxicity.
The results suggest that VIP has a role in the neural control of pelvic organ function and activation of VPAC and/or PACAP receptors can modulate the activity of the autonomic neurons innervating pelvic organs.
Title: VIP and PACAP effects on mouse major pelvic ganglia neurons.
Data show that PACAP neither influenced the survival of JAR cytotrophoblast cells nor affected cellular response to the death-inducing effect of the chemotherapeutic agent methotrexate.
Title: Changes in the expression of pituitary adenylate cyclase-activating polypeptide in the human placenta during pregnancy and its effects on the survival of JAR choriocarcinoma cells.
Data describe PACAP, vasoactive intestinal polypeptide, and PAC1, VPAC1, VPAC2 transcripts or protein expression in urothelium and detrusor smooth muscle and lumbosacral dorsal root ganglia in NGF-overexpressing and wildtype mice.
Title: PACAP/VIP and receptor characterization in micturition pathways in mice with overexpression of NGF in urothelium.
Data demonstrate that STAT3 is involved in PACAP signaling and function during PC12 cell differentiation by the neuropeptide.
Title: Activation of STAT3 by pituitary adenylate cyclase-activating polypeptide (PACAP) during PACAP-promoted neurite outgrowth of PC12 cells.

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General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in integrin activation	ISO Inferred from Sequence Orthology more info
involved_in integrin activation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of immunoglobulin production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of immunoglobulin production	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of B cell proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of B cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of B cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of insulin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of insulin receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
part_of endoplasmic reticulum chaperone complex	IBA Inferred from Biological aspect of Ancestor more info
part_of endoplasmic reticulum chaperone complex	ISO Inferred from Sequence Orthology more info
part_of endoplasmic reticulum chaperone complex	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum lumen	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum lumen	ISS Inferred from Sequence or Structural Similarity more info
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: marginal zone B- and B1-cell-specific protein

Names: plasma cell-induced resident ER protein; plasma cell-induced resident endoplasmic reticulum protein; proapoptotic caspase adapter protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.