Adam33 ADAM metallopeptidase domain 33 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Adam33provided by RGD
Official Full Name: ADAM metallopeptidase domain 33provided by RGD
Primary source: RGD:1305278
See related: EnsemblRapid:ENSRNOG00000021242 AllianceGenome:RGD:1305278
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable metalloendopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; and rhinitis. Orthologous to human ADAM33 (ADAM metallopeptidase domain 33). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 78.4), Lung (RPKM 77.4) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q36

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (138715428..138736392, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (118262395..118283456, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (123595018..123607549, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

soluble ADAM33 overexpression altered the mechanical behaviors of airway smooth muscle cells.
Title: Overexpression of soluble ADAM33 promotes a hypercontractile phenotype of the airway smooth muscle cell in rat.
ADAM33 is a mediator of airway smooth muscle cell dysfunction in asthma.
Title: ADAM33 protein expression and the mechanics of airway smooth muscle cells are highly correlated in ovalbumin-sensitized rats.

Submit: New GeneRIF Correction

General gene information

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Markers

BF386688 (e-PCR)
- UniSTS:243813

d3mgh15 (e-PCR)
- UniSTS:121777

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: disintegrin and metalloproteinase domain-containing protein 33

Names: a disintegrin and metallopeptidase domain 33; a disintegrin and metalloprotease domain 33

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001395113.1 → NP_001382042.1 disintegrin and metalloproteinase domain-containing protein 33 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

F1M8J6

Related

ENSRNOP00000040646.6, ENSRNOT00000051404.8

Conserved Domains (4) summary

smart00050
Location:429 → 503

DISIN; Homologues of snake disintegrins

smart00608
Location:505 → 647

ACR; ADAM Cysteine-Rich Domain

cd04269
Location:213 → 410

ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...

pfam01562
Location:41 → 170

Pep_M12B_propep; Reprolysin family propeptide

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

138715428..138736392 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

RNA

XR_005501878.2 RNA Sequence
XR_005501877.2 RNA Sequence
XR_005501876.2 RNA Sequence
XR_005501879.2 RNA Sequence
XR_005501875.2 RNA Sequence
XR_005501880.2 RNA Sequence
XR_005501881.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001107776.2: Suppressed sequence

Description

NM_001107776.2: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.