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    Ubxn4 UBX domain protein 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304766, updated on 3-Dec-2024

    Summary

    Official Symbol
    Ubxn4provided by RGD
    Official Full Name
    UBX domain protein 4provided by RGD
    Primary source
    RGD:1307451
    See related
    EnsemblRapid:ENSRNOG00000003625 AllianceGenome:RGD:1307451
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ubxd2
    Summary
    Predicted to be involved in ERAD pathway. Predicted to be located in cytosol. Predicted to be active in endoplasmic reticulum. Orthologous to human UBXN4 (UBX domain protein 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Liver (RPKM 244.8), Kidney (RPKM 222.3) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Ubxn4 in Genome Data Viewer
    Location:
    13q13
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (42292346..42324928)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (39740064..39772493)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (44956963..44989653)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene R3H domain containing 1 Neighboring gene U2 spliceosomal RNA Neighboring gene microRNA 128-1 Neighboring gene 60S ribosomal protein L37 pseudogene Neighboring gene transfer RNA proline (anticodon AGG) 78 Neighboring gene lactase Neighboring gene transfer RNA serine (anticodon AGA) 41 Neighboring gene minichromosome maintenance complex component 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in ERAD pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ERAD pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to unfolded protein IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear envelope IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    UBX domain-containing protein 4
    Names
    UBX domain containing 2
    UBX domain-containing protein 2
    erasin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012025.2NP_001012025.1  UBX domain-containing protein 4

      See identical proteins and their annotated locations for NP_001012025.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/Swiss-Prot
      Q5HZY0
      UniProtKB/TrEMBL
      A6IBW9, A6IBX0
      Related
      ENSRNOP00000078558.2, ENSRNOT00000098224.2
      Conserved Domains (2) summary
      smart00166
      Location:318393
      UBX; Domain present in ubiquitin-regulatory proteins
      cl00388
      Location:4113
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      42292346..42324928
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006249699.4XP_006249761.1  UBX domain-containing protein 4 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZL25, A6IBX0
      Related
      ENSRNOP00000004878.6, ENSRNOT00000004878.9
      Conserved Domains (2) summary
      smart00166
      Location:319394
      UBX; Domain present in ubiquitin-regulatory proteins
      cl00388
      Location:4113
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
    2. XM_039090690.2XP_038946618.1  UBX domain-containing protein 4 isoform X2

      UniProtKB/TrEMBL
      A6IBX0
      Conserved Domains (2) summary
      cl00388
      Location:4113
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
      cl28922
      Location:318355
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
    3. XM_063272285.1XP_063128355.1  UBX domain-containing protein 4 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZNR5, A6IBX0
      Related
      ENSRNOP00000079987.1, ENSRNOT00000107083.2