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    Sh2d5 SH2 domain containing 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 366489, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sh2d5provided by RGD
    Official Full Name
    SH2 domain containing 5provided by RGD
    Primary source
    RGD:1305952
    See related
    EnsemblRapid:ENSRNOG00000014909 AllianceGenome:RGD:1305952
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1305952
    Summary
    Predicted to be active in postsynaptic density. Orthologous to human SH2D5 (SH2 domain containing 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 45.7), Spleen (RPKM 6.1) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sh2d5 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (155753087..155763936)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (150469738..150480615)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (156615889..156624962)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene macrophage migration inhibitory factor, pseudogene 5 Neighboring gene heterochromatin protein 1, binding protein 3 Neighboring gene uncharacterized LOC134487021 Neighboring gene kinesin family member 17 Neighboring gene dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Src homology 2 domain containing protein 5 (SH2D5) binds the breakpoint cluster region protein, BCR, and regulates levels of Rac1-GTP. Gray EJ, et al. J Biol Chem, 2014 Dec 19. PMID 25331951, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate that Src homology 2 domain containing protein 5 (SH2D5) controls neuronal morphology via breakpoint cluster region protein BCR and Rac1 GTP binding protein.
      Title: Src homology 2 domain containing protein 5 (SH2D5) binds the breakpoint cluster region protein, BCR, and regulates levels of Rac1-GTP.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    is_active_in postsynaptic density IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    SH2 domain-containing protein 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001431207.1 → NP_001418136.1  SH2 domain-containing protein 5 isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A096MJD8, A6ITG7, D3ZWT6

    2. NM_001431208.1 → NP_001418137.1  SH2 domain-containing protein 5 isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A096MJD8, A6ITG7, D3ZWT6

    3. NM_001431209.1 → NP_001418138.1  SH2 domain-containing protein 5 isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A096MJD8, A6ITG7, D3ZWT6

    4. NM_001431210.1 → NP_001418139.1  SH2 domain-containing protein 5 isoform b

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005

    5. NM_001431211.1 → NP_001418140.1  SH2 domain-containing protein 5 isoform c

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005

    6. NM_001431212.1 → NP_001418141.1  SH2 domain-containing protein 5 isoform c

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005

    7. NM_001431213.1 → NP_001418142.1  SH2 domain-containing protein 5 isoform c

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      155753087..155763936
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039111317.2 → XP_038967245.1  SH2 domain-containing protein 5 isoform X1

      Conserved Domains (2) summary
      cd00173
      Location:302 → 378
      SH2; Src homology 2 (SH2) domain
      cd13157
      Location:23 → 150
      PTB_tensin-related; Tensin-related Phosphotyrosine-binding (PTB) domain

    2. XM_006239286.5 → XP_006239348.1  SH2 domain-containing protein 5 isoform X3

      Conserved Domains (2) summary
      cd00173
      Location:218 → 294
      SH2; Src homology 2 (SH2) domain
      cl17171
      Location:1 → 66
      PH-like; Pleckstrin homology-like domain

    3. XM_006239283.4 → XP_006239345.1  SH2 domain-containing protein 5 isoform X1

      Related
      ENSRNOP00000068008.3, ENSRNOT00000076439.4
      Conserved Domains (2) summary
      cd00173
      Location:302 → 378
      SH2; Src homology 2 (SH2) domain
      cd13157
      Location:23 → 150
      PTB_tensin-related; Tensin-related Phosphotyrosine-binding (PTB) domain

    4. XM_063288638.1 → XP_063144708.1  SH2 domain-containing protein 5 isoform X2

    5. XM_063288637.1 → XP_063144707.1  SH2 domain-containing protein 5 isoform X1

    6. XM_063288639.1 → XP_063144709.1  SH2 domain-containing protein 5 isoform X3

    7. XM_039111316.2 → XP_038967244.1  SH2 domain-containing protein 5 isoform X1

      UniProtKB/TrEMBL
      A0A096MJD8, A6ITG7, D3ZWT6
      Conserved Domains (2) summary
      cd00173
      Location:302 → 378
      SH2; Src homology 2 (SH2) domain
      cd13157
      Location:23 → 150
      PTB_tensin-related; Tensin-related Phosphotyrosine-binding (PTB) domain

    8. XM_039111315.2 → XP_038967243.1  SH2 domain-containing protein 5 isoform X1

      UniProtKB/TrEMBL
      A0A096MJD8, A6ITG7, D3ZWT6
      Conserved Domains (2) summary
      cd00173
      Location:302 → 378
      SH2; Src homology 2 (SH2) domain
      cd13157
      Location:23 → 150
      PTB_tensin-related; Tensin-related Phosphotyrosine-binding (PTB) domain
    Nucleotide Protein Strain
    Heading Accession and Version

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