Dpm1 dolichyl-phosphate mannosyltransferase subunit 1, catalytic [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dpm1provided by RGD
Official Full Name: dolichyl-phosphate mannosyltransferase subunit 1, catalyticprovided by RGD
Primary source: RGD:1310120
See related: EnsemblRapid:ENSRNOG00000010993 AllianceGenome:RGD:1310120
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables D-mannose binding activity; alcohol binding activity; and dolichyl-phosphate beta-D-mannosyltransferase activity. Involved in GDP-mannose metabolic process and dolichol metabolic process. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be part of dolichol-phosphate-mannose synthase complex. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ie. Orthologous to human DPM1 (dolichyl-phosphate mannosyltransferase subunit 1, catalytic). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 149.6), Liver (RPKM 146.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q42

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (177338855..177358398, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (156919979..156939522, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (164966637..164986180, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

BE114634 (e-PCR)
- UniSTS:247611

RH143834 (e-PCR)
- UniSTS:233080

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables D-mannose binding	IDA Inferred from Direct Assay more info	PubMed
enables alcohol binding	IDA Inferred from Direct Assay more info	PubMed
enables dolichyl-phosphate beta-D-mannosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables dolichyl-phosphate beta-D-mannosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables dolichyl-phosphate beta-D-mannosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables dolichyl-phosphate-mannose-protein mannosyltransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in GDP-mannose metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in GPI anchor biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within GPI anchor biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in GPI anchor biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in dolichol metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within dolichol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in dolichol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in dolichol-linked oligosaccharide biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein O-linked mannosylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein O-linked mannosylation	ISO Inferred from Sequence Orthology more info
involved_in protein mannosylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to oxygen levels	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of dolichol-phosphate-mannose synthase complex	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: dolichol-phosphate mannosyltransferase subunit 1

Names: dolichol-phosphate (beta-D) mannosyltransferase 1; dolichyl-phosphate mannosyltransferase 1; dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit

NP_001100014.1

EC 2.4.1.83

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.