Plxna3 plexin A3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Plxna3provided by RGD
Official Full Name: plexin A3provided by RGD
Primary source: RGD:1584973
See related: EnsemblRapid:ENSRNOG00000060464 AllianceGenome:RGD:1584973
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: SEX; Plxn4
Summary: Predicted to enable semaphorin receptor activity. Predicted to be involved in several processes, including nervous system development; positive regulation of cytoskeleton organization; and semaphorin-plexin signaling pathway. Predicted to act upstream of or within several processes, including hippocampus development; negative regulation of axon extension involved in axon guidance; and neuron development. Predicted to be part of semaphorin receptor complex. Predicted to be active in plasma membrane. Orthologous to human PLXNA3 (plexin A3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 35.9), Adrenal (RPKM 33.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq37

Exon count:: 33

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (157266986..157282896)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (152115699..152131608)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (156363400..156379433, complement)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results suggest that plexin A3 is expressed in OPCs and immature oligodendrocytes and is involved in OPC migration.
Title: Plexin A3 is involved in semaphorin 3F-mediated oligodendrocyte precursor cell migration.

Submit: New GeneRIF Correction

General gene information

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Markers

REN89674 (e-PCR)
- UniSTS:414472

REN89678 (e-PCR)
- UniSTS:414476

RH131167 (e-PCR)
- UniSTS:214450

Son (e-PCR), detects polymorphism
- UniSTS:527563

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables semaphorin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables semaphorin receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of axon extension involved in axon guidance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within axon guidance	ISO Inferred from Sequence Orthology more info
involved_in branchiomotor neuron axon guidance	ISO Inferred from Sequence Orthology more info
involved_in facial nerve structural organization	ISO Inferred from Sequence Orthology more info
involved_in gonadotrophin-releasing hormone neuronal migration to the hypothalamus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hippocampus development	ISO Inferred from Sequence Orthology more info
involved_in motor neuron axon guidance	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative chemotaxis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of axon extension involved in axon guidance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron projection extension	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron projection guidance	ISO Inferred from Sequence Orthology more info
involved_in olfactory nerve formation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytoskeleton organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within pyramidal neuron development	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in semaphorin-plexin signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in semaphorin-plexin signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in synapse assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in trigeminal nerve structural organization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of semaphorin receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: plexin-A3

Names: Plexin 4, SEX, homolog to the cMet/HGF receptors

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107581.2 → NP_001101051.2 plexin-A3 precursor

See identical proteins and their annotated locations for NP_001101051.2

Status: PROVISIONAL

Source sequence(s)

AC094668

UniProtKB/Swiss-Prot

D3ZPX4

Related

ENSRNOP00000068735.1, ENSRNOT00000083148.3

Conserved Domains (8) summary

cd11273
Location:22 → 490

Sema_plexin_A3; The Sema domain, a protein interacting module, of Plexin A3

smart00423
Location:638 → 685

PSI; domain found in Plexins, Semaphorins and Integrins

cd00603
Location:1126 → 1209

IPT_PCSR; IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the ...

cd01179
Location:936 → 1022

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:841 → 935

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01181
Location:1024 → 1124

IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:491 → 531

PSI; Plexin repeat

pfam08337
Location:1295 → 1842

Plexin_cytopl; Plexin cytoplasmic RasGAP domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

157266986..157282896

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006229577.5 → XP_006229639.1 plexin-A3 isoform X1

See identical proteins and their annotated locations for XP_006229639.1

UniProtKB/Swiss-Prot

D3ZPX4

Conserved Domains (8) summary

cd11273
Location:22 → 490

Sema_plexin_A3; The Sema domain, a protein interacting module, of Plexin A3

smart00423
Location:638 → 685

PSI; domain found in Plexins, Semaphorins and Integrins

cd00603
Location:1126 → 1209

IPT_PCSR; IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the ...

cd01179
Location:936 → 1022

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:841 → 935

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01181
Location:1024 → 1124

IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:491 → 531

PSI; Plexin repeat

pfam08337
Location:1295 → 1842

Plexin_cytopl; Plexin cytoplasmic RasGAP domain
XM_039099684.2 → XP_038955612.1 plexin-A3 isoform X2

Conserved Domains (9) summary

cd00603
Location:861 → 944

IPT_PCSR; IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the ...

cd01179
Location:671 → 757

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:576 → 670

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01181
Location:759 → 859

IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:226 → 263

PSI; Plexin repeat

pfam08337
Location:1029 → 1577

Plexin_cytopl; Plexin cytoplasmic RasGAP domain

pfam17960
Location:281 → 372

TIG_plexin; TIG domain

pfam18020
Location:426 → 520

TIG_2; TIG domain found in plexin

cl15693
Location:1 → 225

Sema; The Sema domain, a protein interacting module, of semaphorins and plexins