U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Ppp1r14b protein phosphatase 1, regulatory (inhibitor) subunit 14B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 259225, updated on 27-Nov-2024

    Summary

    Official Symbol
    Ppp1r14bprovided by RGD
    Official Full Name
    protein phosphatase 1, regulatory (inhibitor) subunit 14Bprovided by RGD
    Primary source
    RGD:628702
    See related
    AllianceGenome:RGD:628702
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    PHI-1
    Summary
    Enables phosphatase inhibitor activity and protein phosphatase regulator activity. Predicted to be involved in innate immune response. Predicted to be located in cytoplasm and membrane. Orthologous to human PPP1R14B (protein phosphatase 1 regulatory inhibitor subunit 14B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Muscle (RPKM 495.2), Thymus (RPKM 494.8) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ppp1r14b in Genome Data Viewer
    Location:
    1q43
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (213594416..213596527)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (204165210..204167320)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (222229835..222231945)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene BCL2-associated agonist of cell death Neighboring gene phospholipase C beta 3 Neighboring gene FKBP prolyl isomerase 2 like 1 Neighboring gene FKBP prolyl isomerase 2 Neighboring gene vascular endothelial growth factor B

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    protein phosphatase 1 regulatory subunit 14B
    Names
    phosphatase holoenzyme inhibitor 1
    protein phosphatase 1, regulatory (inhibitor) 5 subunit 14B
    ubiquitous PKC-potentiated PP1 inhibitor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172045.1NP_742042.1  protein phosphatase 1 regulatory subunit 14B

      See identical proteins and their annotated locations for NP_742042.1

      Status: PROVISIONAL

      Source sequence(s)
      AY122323
      UniProtKB/Swiss-Prot
      Q8K3F3
      UniProtKB/TrEMBL
      A0A8I6G618
      Conserved Domains (1) summary
      pfam05361
      Location:51147
      PP1_inhibitor; PKC-activated protein phosphatase-1 inhibitor

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      213594416..213596527
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)